Background: Breast cancer survivors (BCS) experience long-term adverse effects, with breast cancer-related lymphedema (BCRL) being one of the most common complications. Exercise is suggested as a safe strategy to improve functionality in BCS with or at risk of developing BCRL. However, the effects of concurrent training in these patients are poorly understood. The aim of the study was to analyze the effects of a 12-week supervised concurrent training program and a 12-week follow-up period without training on molecular, functional, and clinical outcomes in BCS.Methods: A single-arm study was conducted in 11 BCS with or at risk of BCRL to analyze the effects of a 12-week concurrent training and a 12-week follow-up period on molecular (92 inflammation-related proteins), functional (upper- and lower-body strength, handgrip strength, and cardiorespiratory fitness), and clinical (body mass index, arm volume, subcutaneous and muscle thickness, range of motion, physical activity levels and heart rate variability, pain, and quality of life [QoL]) outcomes.Results: The 12-week concurrent training program significantly improved upper-body muscle strength, handgrip strength, pain, emotional well-being, and total QoL. In addition, after the 12-week follow-up period, the increase in row strength was maintained, and a significant decrease in various inflammation-related proteins was observed.Conclusions: A 12-week concurrent training program improved strength, pain, and QoL in BCS without increasing inflammation. After the follow-up period, inflammation-related protein levels decreased, and row strength gains were maintained, supporting the potential effects of concurrent training. Further larger and controlled studies are needed to confirm the results.
背景：乳腺癌幸存者（BCS）会经历长期不良影响，其中乳腺癌相关淋巴水肿（BCRL）是最常见的并发症之一。运动被认为是改善伴有或存在BCRL风险的BCS患者功能的安全策略。然而，目前对于这些患者进行同步训练的效果了解甚少。本研究旨在分析为期12周的监督性同步训练计划以及随后12周无训练随访期对BCS患者分子、功能和临床指标的影响。 方法：本研究为单臂研究，纳入了11名伴有或存在BCRL风险的BCS患者，分析12周同步训练及12周随访期对分子指标（92种炎症相关蛋白）、功能指标（上肢与下肢力量、握力、心肺适能）及临床指标（体重指数、手臂体积、皮下及肌肉厚度、关节活动度、体力活动水平与心率变异性、疼痛及生活质量[QoL]）的影响。 结果：12周同步训练显著提高了患者的上肢肌肉力量、握力，并改善了疼痛、情绪健康及总体生活质量。此外，在12周随访期结束后，划船力量的增长得以维持，并且观察到多种炎症相关蛋白水平显著下降。 结论：为期12周的同步训练在不增加炎症的情况下，改善了BCS患者的力量、疼痛和生活质量。随访期结束后，炎症相关蛋白水平下降，划船力量的增长得以维持，这支持了同步训练的潜在益处。未来需要更大规模且设置对照的研究来验证这些结果。
肿瘤(癌症)患者之家