Transplant oncology is a rapidly evolving discipline that incorporates oncology, transplant medicine, and surgery. As the field continues to grow, there remains an opportunity to enhance patient selection, detect recurrence after liver transplantation, and optimize treatment after recurrence. Liquid biopsies are an emerging resource to improve patient care. In this review, we evaluate the most recent available data on circulating tumor DNA and how it pertains to primary and metastatic hepatobiliary malignancies. We discuss the opportunities and current limitations to clinical practice, especially in relation to total hepatectomy and liver transplantation. We conclude that as both transplant oncology and our understanding of circulating tumor DNA continue to evolve, rigorous, prospective study is required to integrate this technology into a clinical paradigm.
移植肿瘤学是一门融合肿瘤学、移植医学与外科手术的快速发展的学科。随着该领域的持续扩展，在优化患者选择、监测肝移植后复发以及制定复发后治疗方案方面仍存在提升空间。液体活检技术正成为改善患者诊疗的新兴手段。本文综述了当前关于循环肿瘤DNA的最新研究数据及其在原发性与转移性肝胆恶性肿瘤中的应用价值，探讨了该技术在临床实践中的机遇与现存局限，尤其关注其在全肝切除与肝移植领域的应用前景。我们认为，随着移植肿瘤学与循环肿瘤DNA认知的持续发展，需要通过严谨的前瞻性研究将该技术整合到临床诊疗体系中。
肿瘤(癌症)患者之家