Background/Objectives: Actinic keratosis (AK) is considered to be the most common form of in situ carcinoma and typically arises on skin that has been chronically exposed to ultraviolet radiation. The need for early diagnosis, using non-invasive methods, has allowed for a non-surgical approach to these conditions with a significant impact on the quality of life of patients. Methods: A retrospective study was conducted on 58 patients diagnosed with AK who underwent surgical excision at a tertiary center in Bucharest, Romania between 2018 and 2023. Clinical parameters (age, sex, lesion size, anatomical location, comorbidities) and histopathological variables (AK subtype, KIN grade, pleomorphism, solar elastosis, inflammatory infiltrate) were analyzed. Statistical associations between histological findings and clinical features were assessed using Fisher’s exact test. Conclusions: The study confirmed a predominance of AK among elderly patients, with hypertrophic lesions and moderate dysplasia (KIN II) being most common. Higher KIN grades correlated significantly with more severe pleomorphism, solar elastosis, and inflammatory response, suggesting progressive UV-induced skin damage. The findings underscore the importance of clinicopathological correlation for risk stratification and support the integration of non-invasive diagnostic tools to improve early detection and management of AK.
背景/目的：光化性角化病（AK）被认为是最常见的原位癌形式，通常发生于长期暴露于紫外线辐射的皮肤。早期诊断的需求促使采用非侵入性方法，从而实现了对此类疾病的无创处理，显著改善了患者的生活质量。方法：本研究对2018年至2023年间在罗马尼亚布加勒斯特一家三级医疗中心接受手术切除的58例AK确诊患者进行了回顾性分析。分析了临床参数（年龄、性别、病变大小、解剖位置、合并症）和组织病理学变量（AK亚型、KIN分级、多形性、日光性弹力纤维变性、炎症浸润），并采用Fisher精确检验评估了组织学结果与临床特征之间的统计学关联。结论：研究证实AK在老年患者中占主导地位，其中肥厚性病变和中度不典型增生（KIN II级）最为常见。较高的KIN分级与更显著的多形性、日光性弹力纤维变性和炎症反应显著相关，提示紫外线引起的皮肤损伤呈渐进性发展。这些发现强调了临床病理学关联在风险分层中的重要性，并支持整合非侵入性诊断工具以提升AK的早期检测和治疗水平。
肿瘤(癌症)患者之家