Background: This study aims to analyze the clinical, radiological, and histopathological features, as well as the long-term follow-up, of patients with breast carcinoma orbital metastases.Methods: The study was a multicentric retrospective observational case series. The medical records of 32 female patients affected by breast carcinoma orbital metastases referred to three tertiary referral centers from January 2016 to December 2023 were reviewed. The demographic characteristics of the population, clinical ophthalmological presentation, histological features, orbital metastasis latency, disease-related survival (DRS), and mortality rate were analyzed.Results: The median age of the patients was 62.50 years (interquartile range (IQR): 74.50–57.50). The prevalent histotype of the orbital metastases of breast cancer was lobular carcinoma (75.00% of cases). The median orbital metastasis latency time was 39.50 months (IQR: 134.00–10.25). The median disease-related survival (DRS) during the observational period was 35 months, and the 24-month survival rate was 70.73%. The overall mortality rate in our population was 50%.Conclusions: The most frequent histotype of breast cancer orbital metastasis is lobular carcinoma. The primary tumor precedes the onset of orbital metastasis in most cases and usually presents as a mass occupying space and infiltrating the orbit. Orbital metastases are a sign of an advanced stage of the disease, which has a high mortality rate and a low DRS.
背景：本研究旨在分析乳腺癌眼眶转移患者的临床、影像学及组织病理学特征，并探讨其长期随访结果。 方法：本研究为多中心回顾性观察性病例系列研究。回顾性分析了2016年1月至2023年12月期间三家三级转诊中心收治的32例乳腺癌眼眶转移女性患者的医疗记录。对患者的人口学特征、眼科临床表现、组织学特征、眼眶转移潜伏期、疾病相关生存期（DRS）及死亡率进行了分析。 结果：患者中位年龄为62.50岁（四分位距（IQR）：74.50–57.50）。乳腺癌眼眶转移最常见的组织学类型为小叶癌（占病例的75.00%）。眼眶转移的中位潜伏期为39.50个月（IQR：134.00–10.25）。观察期内中位疾病相关生存期（DRS）为35个月，24个月生存率为70.73%。研究人群的总死亡率为50%。 结论：乳腺癌眼眶转移最常见的组织学类型为小叶癌。在大多数病例中，原发肿瘤先于眼眶转移发生，通常表现为占位性肿块并浸润眼眶。眼眶转移是疾病晚期的标志，具有高死亡率和低疾病相关生存期的特点。
肿瘤(癌症)患者之家