文章：

肺癌患者中的口咽癌与口腔癌：其预后是否比单纯肺癌患者更差？

Oropharyngeal and Oral Cancer in Lung Cancer Patients: Do They Present a Worse Prognosis than Isolated Lung Cancer Patients?

原文发布日期：31 May 2025

DOI: 10.3390/cancers17111850

类型: Article

开放获取: 是

英文摘要：

Background/objectives:Second primary lung cancer frequently manifests in individuals who have survived head and neck cancer, with this occurrence often being attributed to shared risk factors. The objective of the present study is to compare the prognosis, in terms of survival rate, of patients who presented isolated bronchogenic carcinoma (BC) with that of patients who presented with a personal history of BC and associated oropharyngeal and oral cancer (OAOC).Methods:A retrospective longitudinal study was conducted, including all consecutive patients who underwent surgical resection with curative intent for BC in Hospital Clínico San Carlos (HCSC), Madrid, Spain, between December 1989 and December 2024. The survival rate was calculated and compared in two groups of patients: Group 1: 1594 patients with isolated BC and Group 2: 97 patients with BC and OAOC.Results:Group 2 did not show a significant difference in their 60-month survival rate in comparison to Group 1 (HR = 1.23, CI 95% 0.9–1.6)p= 0.14. But when comparing the 120-month survival rate, Group 1 showed a significantly higher survival rate (36.4%, CI 95% 33.9–39%) compared to Group 2, (25.54%, CI 95% 17.78–36.7%) HR= 1.28 (CI 95% 1–1.6),p= 0.04. Disease-free survival showed a non-significant trend of greater severity among patients with a previous history of OAOC.Conclusions: Lung cancer patients who presented with OAOC had worse overall survival compared to patients who presented with isolated lung cancer, and a significant difference was observed at 120 months of follow-up.

摘要翻译： 

背景/目的：头颈癌幸存者中常出现第二原发肺癌，这一现象通常归因于共同的风险因素。本研究旨在比较孤立性支气管源性肺癌（BC）患者与既往有BC病史并伴有口咽及口腔癌（OAOC）患者的生存率预后差异。 方法：本研究为回顾性纵向研究，纳入了1989年12月至2024年12月期间在西班牙马德里圣卡洛斯临床医院（HCSC）接受以治愈为目的手术切除的所有连续BC患者。将患者分为两组进行生存率计算与比较：第一组为1594例孤立性BC患者；第二组为97例BC合并OAOC患者。 结果：与第一组相比，第二组患者的60个月生存率未显示出显著差异（HR = 1.23，95% CI 0.9–1.6，p=0.14）。但在比较120个月生存率时，第一组患者生存率（36.4%，95% CI 33.9–39%）显著高于第二组（25.54%，95% CI 17.78–36.7%），HR=1.28（95% CI 1–1.6），p=0.04。无病生存期分析显示，有OAOC病史的患者呈现更严重的非显著性趋势。 结论：与孤立性肺癌患者相比，伴有OAOC的肺癌患者总生存期更差，且在120个月随访期观察到显著差异。

原文链接：

Oropharyngeal and Oral Cancer in Lung Cancer Patients: Do They Present a Worse Prognosis than Isolated Lung Cancer Patients?