Background: this overview of systematic reviews with meta-analysis summarized the epidemiology of suicide in cancer, mainly focused on prevalence, incidence, and risk. Methods: the CINAHL (via EBSCOhost), Embase, PsycINFO (via ProQuest), and PubMed databases were searched from inception to February 2024. AMSTAR 2 evaluated the methodological quality of reviews. The degree of overlap between reviews was calculated. Results: Twelve systematic reviews with meta-analysis were included. The prevalence of suicidal ideation in prostate cancer was 9.85% (95%CI 7.31–12.70%). The relative risk of suicidal ideation in prostate cancer was 2.01 (95%CI: 1.52–2.64) in comparison to controls without this type of cancer during the first 12 months after diagnosis. Furthermore, the risk of suicidal ideation was higher among individuals with bladder cancer in comparison to people without this clinical condition (HR 1.90, 95%CI 1.29−2.81). The crude suicide mortality rate per 100,000 person-years in prostate cancer was 47.1 per 100,000 person-years (95%CI 39.85–54.96). Incidence suicide death per 100,000 person-years was higher in sarcoma (60.99 per 100,000 person-years, 95%CI 17.37–214.19), esophagus (87.71 per 100,000 person-years, 95%CI 27.42–280.54), and pancreas (75.39 per 100,000 person-years, 95%CI 41.80–135.97). Finally, the standardized mortality ratio by suicide was higher in the pancreas (SMR 6.42, 95%CI 1.60–25.76), bone and cartilage (SMR 9.59, 95%CI 1.54–59.77), and mesothelioma (SMR 13.07, 95%CI 1.61–105.80). Conclusions: overall, meta-analyses underlined the relevance of suicide mortality in different cancer sites and geographical regions. Some meta-analyses also found suicidal ideation may be important in prostate or bladder cancer.
背景：本项系统综述与荟萃分析概述旨在总结癌症患者自杀的流行病学特征，主要聚焦于患病率、发病率和风险。方法：检索CINAHL（通过EBSCOhost）、Embase、PsycINFO（通过ProQuest）和PubMed数据库，时间范围为建库至2024年2月。采用AMSTAR 2工具评估综述的方法学质量，并计算各综述间的重叠程度。结果：共纳入12项系统综述与荟萃分析。前列腺癌患者自杀意念的患病率为9.85%（95%CI 7.31–12.70%）。诊断后12个月内，与未患该癌症的对照组相比，前列腺癌患者出现自杀意念的相对风险为2.01（95%CI: 1.52–2.64）。此外，膀胱癌患者出现自杀意念的风险高于未患该疾病的人群（HR 1.90, 95%CI 1.29−2.81）。前列腺癌的粗自杀死亡率（每10万人年）为47.1（95%CI 39.85–54.96）。肉瘤（每10万人年60.99，95%CI 17.37–214.19）、食管癌（每10万人年87.71，95%CI 27.42–280.54）和胰腺癌（每10万人年75.39，95%CI 41.80–135.97）的自杀死亡率（每10万人年）较高。最后，胰腺癌（SMR 6.42, 95%CI 1.60–25.76）、骨与软骨癌（SMR 9.59, 95%CI 1.54–59.77）和间皮瘤（SMR 13.07, 95%CI 1.61–105.80）的自杀标准化死亡比较高。结论：总体而言，荟萃分析强调了不同癌症部位和地理区域中自杀死亡率的重要性。部分荟萃分析还发现，自杀意念在前列腺癌或膀胱癌患者中可能较为突出。
肿瘤(癌症)患者之家