Branched-chain amino acids (BCAAs) are essential for protein synthesis and play a crucial role in activating signaling pathways that regulate cell growth and division. Growing evidence reveals their complex role in cancer, particularly in how they support the metabolic reprogramming of tumor cells. BCAAs contribute to an environment that promotes tumor growth and survival by affecting energy balance and key cellular signaling networks. This review highlights recent advances in understanding how BCAAs influence cancer metabolism, emphasizing their dual function as both essential nutrients and sources of metabolic fuel. It also explores how BCAAs interact with other metabolic pathways, revealing potential targets for therapy. By uncovering these cancer-specific dependencies on BCAAs, this work points to promising strategies for disrupting tumor progression and developing new treatment approaches.
支链氨基酸（BCAAs）是蛋白质合成的必需物质，并在激活调控细胞生长与分裂的信号通路中发挥关键作用。越来越多的证据揭示了其在癌症中的复杂作用，尤其是在支持肿瘤细胞代谢重编程方面。BCAAs通过影响能量平衡和关键细胞信号网络，营造出促进肿瘤生长与存活的微环境。本综述重点阐述了近期在理解BCAAs如何影响癌症代谢方面的研究进展，强调其作为必需营养素和代谢燃料来源的双重功能，并探讨了BCAAs与其他代谢途径的相互作用，从而揭示潜在的治疗靶点。通过揭示癌症对BCAAs的特异性依赖，本研究为阻断肿瘤进展和开发新型治疗策略指明了前景广阔的方向。
肿瘤(癌症)患者之家