Background/Objectives: This study aimed to demonstrate the higher efficacy of cryotherapy in temperature reduction in the upper compared to the lower extremity when used for prevention of chemotherapy-induced peripheral neuropathy (CIPN).Methods: This study was conducted between May 2020 and January 2023 at the Department of Obstetrics and Gynecology at the Medical University of Innsbruck. The analysis included all patients from the CROPSI study who received cryotherapy on their upper (UEX) and lower extremity (LEX) and had completed all assessments from start to end of chemotherapy as well as follow-up. The assessments included temperature measurements and neurological tests during CT and at follow-up after completion of CT.Results: Of the 97 patients recruited in the study, 50 completed all assessments and were therefore included in this analysis. Cryotherapy was more effective when cooling was applied to the upper extremity compared to the lower. On the upper extremity, cryotherapy achieved a cooling effect of 12.5 °C compared to 9.6 °C on the lower extremity (p< 0.001). Patients scored better in both neurological tests on their upper extremity compared to lower. Regarding side effects, there was no significant difference between upper and lower extremities. No severe side effects were reported for either location.Conclusions: Our study suggests that currently available devices for continuous cooling for cryotherapy are significantly more effective on the upper extremity.
背景/目的：本研究旨在证明在预防化疗所致周围神经病变（CIPN）时，冷冻疗法对上肢的降温效果优于下肢。 方法：本研究于2020年5月至2023年1月期间在因斯布鲁克医科大学妇产科进行。分析纳入了CROPSI研究中所有接受上肢（UEX）和下肢（LEX）冷冻治疗，并完成化疗全程及随访评估的患者。评估内容包括化疗期间及化疗结束后随访时的体温测量和神经功能测试。 结果：在研究招募的97名患者中，50名完成了所有评估并被纳入本次分析。与下肢相比，冷冻疗法在上肢的应用效果更佳。上肢的冷冻降温效果达到12.5°C，而下肢为9.6°C（p<0.001）。患者在上肢的两项神经功能测试中均表现优于下肢。在副作用方面，上肢与下肢之间无显著差异。两个部位均未报告严重副作用。 结论：我们的研究表明，目前用于持续冷冻治疗的设备在上肢的应用效果显著优于下肢。
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