Background/Objectives: Recently, many researchers have evaluated various viruses, including polyomaviruses (JCV, BKV) and EBV, as potential factors playing a role in the development and/or progression of prostate cancer (PCa), one of the most common cancers in men. Therefore, we aimed to assess the frequency of the JCPyV DNA in tissue collected from PCa patients.Methods: We detected the presence of viral DNA (PCR) in 49.6% of clinical samples, including 71.9% with single EBV infection and 28.1% with EBV/JCV co-infection. We did not detect BKV or a single JCV infection. Therefore, we compared patients with EBV mono-infection with EBV/JCV co-infected patients in the context of risk group, Gleason score, and TNM classification.Results: Our results showed differences in clinicopathological features between single EBV infection and EBV/JCV co-infection. In the group of patients with single EBV infection, most patients were classified as medium/high risk, while in the group with EBV/JCV co-infection, most patients were classified as low risk.Conclusions: Among patients with single EBV infection, a more advanced stage of cancer was observed than in EBV/JCV co-infection. Moreover, the level of anti-EBVCA and anti-EBNA antibodies as well as EBV load was higher in the case of single infection compared to EBV/JCV co-infection. Higher antibody levels were detected in more advanced tumor stages in single EBV infection. Does JCV only “reside” in prostate cells or is it a co-factor in EBV infection? In light of these studies, there is a need to clarify the role of JCV virus in the development and/or progression of prostate cancer.
背景/目的：近年来，许多研究者评估了多种病毒作为前列腺癌（男性最常见癌症之一）发生和/或进展潜在因素的作用，包括多瘤病毒（JCV、BKV）和EB病毒。因此，我们旨在评估前列腺癌患者组织中JCPyV DNA的检出频率。方法：我们在49.6%的临床样本中检测到病毒DNA（PCR），其中71.9%为单一EBV感染，28.1%为EBV/JCV共感染。未检测到BKV或单一JCV感染。因此，我们根据风险分级、格里森评分和TNM分期，对EBV单一感染患者与EBV/JCV共感染患者进行了比较。结果：研究结果显示单一EBV感染与EBV/JCV共感染在临床病理特征上存在差异。在单一EBV感染组中，多数患者被归类为中/高风险；而在EBV/JCV共感染组中，多数患者被归类为低风险。结论：与EBV/JCV共感染相比，单一EBV感染患者的前列腺癌分期更晚。此外，单一EBV感染患者的抗EBVCA抗体、抗EBNA抗体水平及EBV载量均高于EBV/JCV共感染患者。在单一EBV感染中，更晚期的肿瘤分期检测到更高的抗体水平。JCV仅是“定植”于前列腺细胞，还是EBV感染的协同因子？基于这些研究，有必要进一步阐明JCV病毒在前列腺癌发生和/或进展中的作用。
肿瘤(癌症)患者之家