Background/Objectives: Several histopathological risk factors have been examined in vulvar cancer (VC) so far. However, the prognostic relevance of morphological biomarkers such as tumor budding (TB) and poorly defined clusters (PDCs) remains to be determined.Material and Methods:We histologically analyzed the formation of peritumoral and intratumoral TB and PDCs in a cohort of 157 patients with VC. We assessed their association with clinico-pathological features and evaluated their prognostic impact in terms of the risk of local recurrence and occurrence of metastasis (Fisher’s exact test) as well as overall survival (Log-rank test).Results:We determined a distinct prognostic relevance of peritumoral TB with regard to occurrence of metastasis (Fisher’s exact test;p= 0.0415) as well as a significant reduced risk of local recurrence in the group with absent intratumoral TB (Fisher’s exact test;p= 0.0004). Furthermore, we showed that patients without peritumoral budding formation had a significant superior prognosis in terms of overall survival (p= 0.0366, x2= 4.370).Conclusions:This study shows that several new histomorphological biomarkers may serve useful in predicting the clinical course of patients with VC, identifying patients at a lower risk of developing metastases/local recurrence as well as improved overall survival.
背景/目的：迄今为止，外阴癌（VC）中已研究多种组织病理学风险因素。然而，肿瘤出芽（TB）和边界不清细胞簇（PDCs）等形态学生物标志物的预后相关性仍有待确定。材料与方法：我们对157例外阴癌患者的瘤周及瘤内TB和PDCs形成情况进行了组织学分析。评估其与临床病理特征的相关性，并分析其对局部复发风险、转移发生风险（Fisher精确检验）以及总生存期（Log-rank检验）的预后影响。结果：研究发现瘤周TB与转移发生存在显著预后相关性（Fisher精确检验；p=0.0415），且无瘤内TB组患者的局部复发风险显著降低（Fisher精确检验；p=0.0004）。此外，研究显示无瘤周出芽形成的患者总生存期显著更优（p=0.0366，χ²=4.370）。结论：本研究表明，多种新型组织形态学生物标志物可用于预测外阴癌患者的临床病程，有助于识别转移/局部复发风险较低且总生存期更优的患者群体。
肿瘤(癌症)患者之家