文章：

揭示结直肠癌筛查新趋势：聚焦年轻患者群体

Revealing New Patterns in Colorectal Cancer Screening with a Focus on a Younger Patient Population

原文发布日期：16 May 2025

DOI: 10.3390/cancers17101686

类型: Article

开放获取: 是

英文摘要：

Colorectal cancer (CRC) continues to impart a significant mortality burden in the United States, with a growing number of cases affecting younger individuals. In this study, we set out to characterize predictors of missed colorectal cancer screening in a general and age-stratified population.Methods: We analyzed a patient population of over 85,000 patients who presented to a large outpatient network in the Baltimore, Maryland area and were due for CRC screening. We analyzed different characteristics, including race, occupation, relationship status, tobacco smoking status, and body mass index, of patients up to date and overdue on their CRC screening. The majority (over 99%) of our patient population was insured. We performed this analysis on the patient population as a whole and as an age-stratified patient population.Results: In our overall patient population, all of the aforementioned characteristics were significantly different between patients up to date and those overdue on CRC screening. Races with the highest up-to-date CRC screening proportion were Pacific Islanders, East Asian, and White patients, while Asian Indian patients had the lowest up-to-date percentage. Non-employed patients (including patients with disabilities and students), single patients, and current or past tobacco smokers were all found to have significantly lower percentages of up-to-date patients as compared to other groups within these categories. BMI was significantly lower in up-to-date patients. In our age-stratified analysis, younger patients had a significantly lower percentage of up-to-date patients. Notably, younger patients had a significantly higher proportion of patients electing for noninvasive screening modalities.Conclusions: These disparities in CRC screening warrant targeted interventions to minimize future risk of heightened mortality in certain patient populations.

摘要翻译： 

结直肠癌在美国仍造成显著的死亡负担，且年轻患者病例数持续增长。本研究旨在分析普通人群及年龄分层人群中结直肠癌筛查缺失的预测因素。方法：我们分析了马里兰州巴尔的摩地区大型门诊网络中超过85,000名符合结直肠癌筛查条件的患者。通过对比按时接受筛查与筛查超期患者的多项特征（包括种族、职业、婚姻状况、吸烟状况及体重指数）进行分析。研究人群绝大多数（超过99%）拥有医疗保险。分析过程涵盖整体人群及年龄分层人群。结果：在整体人群中，按时筛查组与超期筛查组在所有分析特征上均存在显著差异。太平洋岛民、东亚裔和白人患者的按时筛查率最高，而印度裔患者的按时筛查率最低。无业人员（包括残疾人和学生）、单身者、当前或既往吸烟者的按时筛查率均显著低于同类别其他群体。按时筛查患者的体重指数显著更低。年龄分层分析显示，年轻患者的按时筛查率显著偏低，值得注意的是该群体选择无创筛查方式的比例显著更高。结论：结直肠癌筛查中存在的这些差异提示需要针对特定人群采取干预措施，以降低其未来因筛查不足导致的死亡风险升高。

原文链接：

Revealing New Patterns in Colorectal Cancer Screening with a Focus on a Younger Patient Population