文章：

原发性皮肤淋巴瘤的头皮受累——临床表现、诊断与治疗的最新进展

Scalp Involvement in Primary Cutaneous Lymphomas—An Update on Clinical Presentation, Diagnostics, and Management

原文发布日期：16 May 2025

DOI: 10.3390/cancers17101678

类型: Article

开放获取: 是

英文摘要：

Primary cutaneous lymphomas (PCLs) constitute a heterogeneous group of rare diseases. Previously, few studies have focused on the aspect of scalp involvement by PCLs. The objective of this study was to analyze the clinical presentation, diagnostic pathways, and treatment methods in patients diagnosed with scalp PCLs. A comprehensive literature review was conducted using the PubMed database, with the search terms “scalp” AND “cutaneous lymphoma”, “folliculotropic mycosis fungoides” AND “scalp”, “trichoscopy” AND “lymphoma”, and “dermoscopy” AND “scalp” AND “lymphoma.” The search was limited to articles published from database inception to May 2, 2024. Based on the title and abstract analysis, we included articles on PCLs involving the scalp. After a thorough review of the full manuscripts, several were excluded due to irrelevance, the absence of essential clinical data, discrepancies in patient age, gender, and diagnosis, and a lack of information pertinent to scalp PCLs. The literature search identified 1482 patients with scalp involvement in PCLs. Of the total number of cases, 1096 were diagnosed with B-cell PCLs, 384 with T-cell PCLs, and two cases lacked a precise PCL diagnosis. Primary cutaneous follicle center lymphoma was the most frequently reported B-cell PCL of the scalp, while mycosis fungoides was the most common T-cell PCL. Alopecia was observed in 69.0% of the patients analyzed, with the most prevalent form being non-scarring focal alopecia. It is imperative to consider the scalp in patients with PCLs, particularly in light of the knowledge that some lymphomas affecting the scalp exhibit a higher degree of aggressiveness.

摘要翻译： 

原发性皮肤淋巴瘤是一组异质性罕见疾病。既往研究较少关注其累及头皮的表现。本研究旨在分析头皮原发性皮肤淋巴瘤患者的临床表现、诊断路径及治疗方法。通过PubMed数据库进行系统性文献检索，检索词包括"scalp" AND "cutaneous lymphoma"、"folliculotropic mycosis fungoides" AND "scalp"、"trichoscopy" AND "lymphoma"以及"dermoscopy" AND "scalp" AND "lymphoma"，检索时限为建库至2024年5月2日。根据标题与摘要分析，纳入涉及头皮的原发性皮肤淋巴瘤相关文献。经全文审阅后，排除不相关文献、缺乏关键临床数据者、患者年龄/性别/诊断信息矛盾者及与头皮原发性皮肤淋巴瘤无关的研究。文献检索共发现1482例累及头皮的原发性皮肤淋巴瘤患者，其中1096例为B细胞型，384例为T细胞型，2例缺乏明确分型。原发性皮肤滤泡中心淋巴瘤是头皮最常见的B细胞亚型，蕈样肉芽肿则为最常见的T细胞亚型。在纳入分析的患者中，69.0%出现脱发表现，其中以非瘢痕性局灶脱发最为常见。鉴于部分累及头皮的原发性皮肤淋巴瘤具有更高侵袭性，临床诊疗中必须重视头皮受累情况的评估。

原文链接：

Scalp Involvement in Primary Cutaneous Lymphomas—An Update on Clinical Presentation, Diagnostics, and Management