Background/Objective:Mississippi has the highest breast cancer mortality rate in the nation, yet there remains a limited understanding of the factors currently contributing to breast cancer in the state. This systematic review aims to provide insights into breast cancer epidemiology, disparities, and outcomes in Mississippi by synthesizing existing research published over the past 25 years.Methods:A systematic search of PubMed and Google Scholar identified studies published between 2000 and 2024 that focused on breast cancer in Mississippi. Quality appraisal was performed using the Joanna Briggs Institute (JBI) checklist, and a narrative synthesis approach was used to analyze the findings.Results:The initial literature search yielded 33 articles. After removing duplicates, screening titles and abstracts, and conducting a full-text review, 15 studies met the inclusion criteria. The findings revealed significant racial and geographic disparities in breast cancer incidence, mortality, and access to care. Black women in Mississippi are more likely to be diagnosed in later stages and experience worse outcomes, primarily due to socioeconomic disadvantages, healthcare access barriers, and structural inequities. Geographic barriers, particularly in rural areas, further worsen these disparities.Conclusions:This review identified a scarcity of breast cancer research in Mississippi over the last 25 years, with only three studies in the past 5 years, leaving critical knowledge gaps in understanding current dynamics. This review highlights an urgent need for expanded, Mississippi-specific breast cancer research to better understand the factors driving disparities and to develop culturally tailored, evidence-based interventions to address breast cancer disparities.
背景/目的：密西西比州拥有全美最高的乳腺癌死亡率，然而目前对该州乳腺癌影响因素的认识仍较为有限。本系统综述旨在通过综合过去25年间发表的研究成果，深入剖析密西西比州乳腺癌的流行病学特征、健康差异及临床结局。 方法：通过系统检索PubMed和Google Scholar数据库，筛选出2000年至2024年间聚焦密西西比州乳腺癌的研究文献。采用乔安娜布里格斯研究所（JBI）质量评估工具进行文献质量评价，并运用叙述性综合方法对研究结果进行分析。 结果：初步文献检索获得33篇文献，经过去重、标题摘要筛选及全文审查后，最终纳入15项符合标准的研究。研究结果显示，密西西比州在乳腺癌发病率、死亡率及医疗可及性方面存在显著的种族与地域差异。该州非裔女性更易在晚期确诊且预后较差，主要归因于社会经济劣势、医疗资源获取障碍及结构性不平等问题。地域障碍（特别是农村地区）进一步加剧了这些差异。 结论：本综述发现过去25年间密西西比州乳腺癌研究严重不足，近5年仅有三项相关研究，导致对当前疾病动态认知存在关键空白。本综述强调亟需开展针对密西西比州的本土化乳腺癌研究，以深入理解导致健康差异的驱动因素，并制定符合文化特性、基于循证医学的干预措施来应对乳腺癌健康不平等问题。
Left Behind: The Unmet Need for Breast Cancer Research in Mississippi
肿瘤(癌症)患者之家