Metastasis is the leading cause of cancer-related deaths. During the metastatic cascade, cancer cells tightly interact with immune cells influencing each other in the tumor microenvironment and systemically. Monocytes are important components of immune evasion and critical regulators of cancer progression. They circulate through the bloodstream and contribute to the formation of a pro-tumor microenvironment both in the tumor and pre-metastatic niche. Whereas monocyte participation in cancer development and response to therapy has been described extensively, its impact on metastasis remains a completely uncovered area. This review first summarizes data concerning the influence of monocytes on metastasis formation during their presence in the circulation, primary tumor, and pre-metastatic niche. We also highlight the latest examinations into the clinical relevance of targeting monocytes to prevent metastasis.
转移是癌症相关死亡的主要原因。在转移级联过程中，癌细胞与免疫细胞在肿瘤微环境及全身系统中紧密相互作用、相互影响。单核细胞是免疫逃逸的重要组成部分，也是癌症进展的关键调节因子。它们通过血液循环，在肿瘤及转移前微环境中促进促肿瘤微环境的形成。尽管单核细胞在癌症发展及治疗反应中的作用已有广泛描述，但其对转移的影响仍是一个尚未被揭示的领域。本综述首先总结了单核细胞在循环系统、原发肿瘤及转移前微环境中对转移形成影响的相关数据。同时，我们重点探讨了靶向单核细胞以预防转移的最新临床研究进展。
Immune Evasion in Cancer Metastasis: An Unappreciated Role of Monocytes
肿瘤(癌症)患者之家