文章：

三萜类化合物在黑色素瘤中的化学预防与抗癌活性研究

Chemopreventive and Anticancer Activity of Selected Triterpenoids in Melanoma

原文发布日期：11 May 2025

DOI: 10.3390/cancers17101625

类型: Article

开放获取: 是

英文摘要：

Melanoma is one of the most aggressive forms of skin cancer, characterized by high metastatic potential and resistance to conventional therapies. Natural compounds, particularly terpenoids, have gained attention for their chemopreventive potential and anticancer properties. These plant-derived compounds exhibit diverse biological activities, e.g., cell viability and proliferation inhibition, apoptosis induction, cell cycle regulation, and immune system modulation. The review evaluates the current state of the art on the chemopreventive and anticancer activity of lupane- (betulinic acid), oleanane- (oleanolic acid, β-amyrin, escin, hederagenin, glycyrrhetinic acid), and ursane-type (ursolic acid, asiatic acid, madecassic acid, α-amyrin) triterpenoids in melanoma, highlighting their mechanisms of action, therapeutic potential, and challenges in clinical application.

摘要翻译： 

黑色素瘤是皮肤癌中最具侵袭性的类型之一，其特点是高转移潜力和对常规疗法的耐药性。天然化合物，特别是萜类化合物，因其化学预防潜力和抗癌特性而受到关注。这些植物来源的化合物表现出多种生物活性，例如抑制细胞活力和增殖、诱导细胞凋亡、调节细胞周期以及调节免疫系统。本综述评估了羽扇豆烷型（桦木酸）、齐墩果烷型（齐墩果酸、β-香树脂素、七叶皂苷、常春藤皂苷元、甘草次酸）和乌苏烷型（熊果酸、积雪草酸、羟基积雪草酸、α-香树脂素）三萜类化合物在黑色素瘤中化学预防和抗癌活性的最新研究进展，重点阐述了它们的作用机制、治疗潜力以及临床应用面临的挑战。

原文链接：

Chemopreventive and Anticancer Activity of Selected Triterpenoids in Melanoma