文章：

神经营养因子作为儿童急性淋巴细胞白血病活动性疾病及不良预后的潜在生物标志物

Neurotrophins as Potential Biomarkers for Active Disease and Poor Outcome in Pediatric Acute Lymphoblastic Leukemia

原文发布日期：11 May 2025

DOI: 10.3390/cancers17101623

类型: Article

开放获取: 是

英文摘要：

Background: Neurotrophins (NTs) are pivotal growth factors in cellular development and survival. Their precise implications in Acute Lymphoblastic Leukemia (ALL) remain unclear. Methods: Pediatric ALL samples (2011–2021) were analyzed from a Southern Brazil cohort. Neurotrophin levels were quantified via ELISA, with survival analysis using Kaplan–Meier curves. Gene expression data were sourced from public genomic repositories and analyzed with R software version 4.0.5. Results: At diagnosis, pro-BDNF, BDNF, and NGF levels were significantly lower than in healthy controls. Reduced pro-BDNF correlated with unfavorable outcomes. NGF and sortilin were highly expressed in healthy samples, while BDNF and p75NTRwere predominant in T-ALL and B-ALL, respectively. Conclusions: Neurotrophins show significant alterations in the tumor microenvironment of pediatric ALL. Further studies are needed to elucidate their precise role and prognostic potential.

摘要翻译： 

背景：神经营养因子是细胞发育与存活的关键生长因子，其在急性淋巴细胞白血病中的确切作用机制尚不明确。方法：本研究对巴西南部地区2011-2021年儿童急性淋巴细胞白血病样本进行分析。采用酶联免疫吸附法测定神经营养因子水平，通过Kaplan-Meier曲线进行生存分析，并基于公共基因组数据库获取基因表达数据，使用R软件4.0.5版本进行统计分析。结果：初诊时患者前体脑源性神经营养因子、脑源性神经营养因子及神经生长因子水平显著低于健康对照组，其中前体脑源性神经营养因子降低与不良预后相关。健康样本中神经生长因子及分拣蛋白呈现高表达，而T细胞急淋与B细胞急淋分别以脑源性神经营养因子和p75神经营养因子受体表达为主。结论：神经营养因子在儿童急性淋巴细胞白血病肿瘤微环境中存在显著改变，其具体作用机制及预后价值有待进一步研究阐明。

原文链接：

Neurotrophins as Potential Biomarkers for Active Disease and Poor Outcome in Pediatric Acute Lymphoblastic Leukemia