文章：

慢性髓系白血病患者的工作能力：一项丹麦全国性队列研究

Work Ability in Patients with Chronic Myeloid Leukemia: A Danish Nationwide Cohort Study

原文发布日期：7 May 2025

DOI: 10.3390/cancers17091585

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: Patients with chronic myeloid leukemia (CML) have a long life expectancy due to modern treatment. However, treatment may have adverse effects that hamper work ability.Methods: Patients aged 25–60 years diagnosed in 2002–2020 were included in this nationwide matched cohort study examining work ability from diagnosis (index date), including the need for permanent disability compensation (flexible job or disability pension). Each patient was matched 1:5 on sex, birth year, and level of comorbidity with citizens from the general Danish population without CML. The risks of requiring flexible job and disability pension were calculated by cause-specific hazard ratios (HRs) using Cox proportional hazards regression, and the Aalen–Johansen estimator was used to determine cumulative risks.Results: A total of 489 patients with CML and 2445 matched comparators were included. The median age was 46 years, and males comprised 59.5% of the cohort. Matched comparators were more likely to work at index date and 1, 3, 5, and 10 years after the index date (p< 0.001). The HRs of requiring both flexible job (HR 8.7 (95% confidence interval (CI): 6.1;12.2,p< 0.001)) and disability pension (HR 3.7 (95% CI: 2.8;4.9,p< 0.001)) were higher among patients diagnosed with CML compared to matched comparators. The cumulative risk of requiring flexible job and disability pension also increased in patients with CML compared to matched comparators (p< 0.001).Conclusions: Patients with CML have a reduced work ability compared to the general population. More research is needed to determine the cause of their loss of ability to work.

摘要翻译： 

背景/目的：得益于现代治疗，慢性髓系白血病（CML）患者预期寿命显著延长。然而，治疗可能产生不良影响，进而损害患者的工作能力。方法：本研究为全国性匹配队列研究，纳入2002年至2020年间确诊的25-60岁CML患者，评估其自确诊日（索引日期）起的工作能力状况，包括对永久性残疾补偿（弹性工作岗位或残疾抚恤金）的需求。每位患者按性别、出生年份及合并症程度以1:5比例与丹麦普通无CML人群进行匹配。通过Cox比例风险回归模型计算需要弹性工作岗位及残疾抚恤金的病因特异性风险比（HR），并采用Aalen-Johansen估计量确定累积风险。结果：共纳入489例CML患者及2445例匹配对照者。中位年龄46岁，男性占59.5%。匹配对照者在索引日期及确诊后1年、3年、5年、10年的在岗率均显著更高（p<0.001）。与匹配对照者相比，CML患者需要弹性工作岗位（HR 8.7，95%置信区间[CI]：6.1-12.2，p<0.001）及残疾抚恤金（HR 3.7，95% CI：2.8-4.9，p<0.001）的风险显著升高。CML患者需要弹性工作岗位及残疾抚恤金的累积风险亦显著高于匹配对照者（p<0.001）。结论：与普通人群相比，CML患者的工作能力明显下降。需进一步研究明确其工作能力丧失的具体原因。

原文链接：

Work Ability in Patients with Chronic Myeloid Leukemia: A Danish Nationwide Cohort Study