Background/Objectives: Prostate cancer (PCa) patients frequently experience extended survivorship, highlighting the importance of quality of life (QoL) in cancer care. QoL has been shown to influence survival and PCa progression. For PCa patients, fatigue is a common issue due to cancer itself or its treatments. However, many QoL studies on PCa patients are limited by small sample sizes in clinic settings and often overlook the impact of fatigue and health-related behaviors. To fill this gap, this study aims to evaluate fatigue associated with QoL and related health measures among PCa patients. Methods: This study used the All of Us cohort with 6426 PCa patients. Factors associated with QoL and health outcomes were tested using logistic models. Results: Among PCa patients, 8.8% reported poor QoL, 20.9% reported poor physical health, and 9.0% reported poor mental health. Around 24.5% and 5.0% of PCa patients had a moderate and high fatigue level, respectively. A high fatigue level was significantly associated with poor QoL (OR = 2.33,p< 0.001), poor physical health (OR = 8.20,p< 0.001), and poor mental health (OR = 3.62,p< 0.001), adjusting for other factors. Social function ability also played a critical role in QoL and health outcomes. In addition, PCa therapy was associated with a higher risk of poor physical health (OR = 1.30,p= 0.030) but not associated with QoL and mental health. Conclusions: This study provides valuable insights about fatigue’s important role in QoL, physical health, and mental health for PCa patients. Effective fatigue management is suggested to enhance QoL and overall well-being for PCa patients.
背景/目的：前列腺癌患者常经历较长的生存期，这凸显了生活质量在癌症治疗中的重要性。研究表明生活质量会影响生存率和前列腺癌进展。对于前列腺癌患者而言，因癌症本身或其治疗导致的疲劳是常见问题。然而，许多针对前列腺癌患者生活质量的研究受限于临床样本量较小，且常忽视疲劳及健康相关行为的影响。为填补这一空白，本研究旨在评估前列腺癌患者中与生活质量相关的疲劳及其健康指标。方法：本研究采用"全民健康研究"队列中的6426名前列腺癌患者数据，通过逻辑回归模型分析与生活质量及健康结局相关的因素。结果：在前列腺癌患者中，8.8%报告生活质量较差，20.9%报告身体健康状况不佳，9.0%报告心理健康状况不佳。约24.5%和5.0%的患者分别存在中度和高度疲劳水平。在调整其他因素后，高度疲劳与较差生活质量（OR=2.33，p<0.001）、较差身体健康（OR=8.20，p<0.001）及较差心理健康（OR=3.62，p<0.001）显著相关。社会功能能力对生活质量和健康结局也起关键作用。此外，前列腺癌治疗与较差身体健康风险升高相关（OR=1.30，p=0.030），但与生活质量和心理健康无显著关联。结论：本研究揭示了疲劳在前列腺癌患者生活质量、身体健康和心理健康中的重要作用，建议通过有效的疲劳管理来提升患者生活质量和整体健康水平。
肿瘤(癌症)患者之家