文章：

局部晚期或转移性非透明细胞肾细胞癌的全身治疗

Systemic Treatment of Locally Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma

原文发布日期：30 April 2025

DOI: 10.3390/cancers17091527

类型: Article

开放获取: 是

英文摘要：

Non-clear cell renal cell carcinoma (nccRCC) represents a heterogenous group of malignancies with varying degrees of clinical aggressiveness and response to different systemic therapies. As the characterization of subtypes of nccRCC continues to evolve, it is important to understand the evidence around systemic treatments used in advanced or metastatic stages of specific subtypes. Here, we review the literature on systemic therapies in nccRCC, with a focus on prospective trials that included patients with papillary renal cell carcinoma (RCC), chromophobe RCC, RCC not further classified/unclassified RCC, translocation RCC, collecting duct RCC, and renal medullary carcinoma. We also review emerging treatments for other molecularly defined subtypes of this disease.

摘要翻译： 

非透明细胞肾细胞癌（nccRCC）是一组具有异质性的恶性肿瘤，其临床侵袭性及对不同系统治疗的反应程度存在差异。随着nccRCC亚型特征的不断演变，理解特定亚型在晚期或转移阶段系统治疗的相关证据至关重要。本文综述了nccRCC系统治疗的相关文献，重点关注纳入乳头状肾细胞癌、嫌色细胞肾细胞癌、未进一步分类/未分类肾细胞癌、易位性肾细胞癌、集合管肾细胞癌及肾髓质癌患者的前瞻性试验。同时，本文也探讨了针对该疾病其他分子定义亚型的新兴治疗方法。

原文链接：

Systemic Treatment of Locally Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma