Periodontal disease (PD) is an inflammatory condition that can contribute to the development of oral cancer. Chronic inflammation from PD can lead to the release of inflammatory mediators and growth factors that promote tumorigenesis.Porphyromonas gingivalis(P. gingivalis) is one of several pathogens implicated in PD and its potential link to oral cancer. However, other viral infections, such as human cytomegalovirus (HCMV), can also contribute to chronic inflammation, creating a favorable environment for oral cancer development. Objectives: The present literature review tries to investigate the possible influence ofP. gingivalisand HCMV co-infection in fostering the development of oral cancer and chronic periodontitis. Methods: A comprehensive search was conducted in PubMed and Google Scholar, focusing on the relevance and significance of articles that examine the role ofP. gingivalisand HCMV in periodontal disease and oral cancer. Results: The evidence suggests thatP. gingivalisand HCMV may act synergistically to modulate host immunity, disrupt epithelial integrity, and interfere with key cellular pathways. These interactions may enhance tissue destruction and foster a microenvironment conducive to malignant transformation. However, most of these findings stem from in vitro models and small-scale clinical studies, limiting the generalizability and clinical relevance of current conclusions. Conclusions: Although the proposed interaction betweenP. gingivalisand HCMV provides a compelling framework for understanding how microbial co-infections may influence oral cancer, the evidence remains preliminary and largely associative. To support these mechanistic hypotheses, future studies should give top priority to in vivo models, bigger patient cohorts, and longitudinal clinical studies.
牙周病是一种炎症性疾病，可能促进口腔癌的发生。牙周病引起的慢性炎症可导致炎症介质和生长因子的释放，从而促进肿瘤发生。牙龈卟啉单胞菌是牙周病相关病原体之一，其与口腔癌存在潜在关联。然而，其他病毒感染如人类巨细胞病毒同样可导致慢性炎症，为口腔癌的发展创造有利环境。目的：本文献综述旨在探讨牙龈卟啉单胞菌与人类巨细胞病毒共感染对口腔癌及慢性牙周炎发展的潜在影响。方法：系统检索PubMed和Google Scholar数据库，重点筛选研究牙龈卟啉单胞菌和人类巨细胞病毒在牙周病及口腔癌中作用的文献。结果：现有证据表明，牙龈卟啉单胞菌与人类巨细胞病毒可能通过协同作用调节宿主免疫、破坏上皮完整性并干扰关键细胞通路。这些相互作用可能加剧组织破坏，形成有利于恶性转化的微环境。但当前研究多基于体外模型和小规模临床研究，限制了结论的普适性与临床相关性。结论：虽然牙龈卟啉单胞菌与人类巨细胞病毒的相互作用为理解微生物共感染如何影响口腔癌提供了重要理论框架，但现有证据仍处于初步阶段且多为相关性研究。未来研究应优先开展体内实验、扩大患者队列规模并进行纵向临床研究，以验证相关机制假说。
肿瘤(癌症)患者之家