Preoperative cardiopulmonary exercise testing (CPET) provides an objective measure of a patient’s functional capacity under stress. However, the association between CPET and long-term outcomes for women with ovarian cancer have not been assessed. The aim was to determine whether cardiorespiratory fitness, as measured by CPET parameters—peak oxygen uptake (VO2peak), ventilatory efficiency at anaerobic threshold (VE/VCO2at AT), and anaerobic threshold (AT)—could predict overall survival (OS) and recurrence -free survival (RFS) in patients with all stages of ovarian cancer. Methods: This was a retrospective cohort study of patients who underwent CPET prior to surgery for suspected or confirmed ovarian cancer during 2019–2023 at the Northern Gynaecological Oncology Centre, United Kingdom. CPET outcomes were risk-stratified, with thresholds of AT ≥ 10 mL/min, VO2peak ≥ 15 mL/kg/min, and VE/VCO2at AT ≤ 34 indicating lower risk. Primary outcomes included OS and RFS. Results: A total of 303 patients were included, of whom 56 (18.5%) had a staging laparotomy, 130 (42.9%) underwent primary cytoreductive surgery, and 117 (38.6%) underwent interval cytoreductive surgery. Survival analysis showed that VO2peak ≥ 15 was significantly associated with improved OS of the whole population (p= 0.032). VE/VCO2at AT ≤ 34 was associated with improved survival in patients with advanced stage disease (p= 0.025) after ovarian cancer surgery. There was no association between CPET parameters and RFS. Conclusions: We found that peak VO2≥ 15 was associated with improvement of overall survival in patients with all stages of ovarian cancer. In addition, VE/VCO2at AT ≤ 34 was associated with overall survival in patients with advanced-stage disease.
术前心肺运动试验（CPET）可客观评估患者在应激状态下的功能储备能力。然而，CPET与卵巢癌女性患者长期预后的关联尚未得到充分评估。本研究旨在探讨通过CPET参数——峰值摄氧量（VO2peak）、无氧阈时通气效率（VE/VCO2at AT）及无氧阈（AT）——测量的心肺适能水平，能否预测各分期卵巢癌患者的总生存期（OS）与无复发生存期（RFS）。方法：本研究为回顾性队列研究，纳入2019-2023年间在英国北部妇科肿瘤中心因疑似或确诊卵巢癌接受术前CPET评估的患者。CPET结果按风险分层：AT≥10 mL/min、VO2peak≥15 mL/kg/min、VE/VCO2at AT≤34定义为低风险阈值。主要研究终点为OS与RFS。结果：共纳入303例患者，其中56例（18.5%）接受分期剖腹探查术，130例（42.9%）接受初次肿瘤细胞减灭术，117例（38.6%）接受间歇性肿瘤细胞减灭术。生存分析显示：VO2peak≥15与全人群OS改善显著相关（p=0.032）；VE/VCO2at AT≤34与晚期患者术后生存改善相关（p=0.025）。CPET参数与RFS无显著关联。结论：研究发现VO2peak≥15与各分期卵巢癌患者总生存期改善相关，而VE/VCO2at AT≤34与晚期患者总生存期改善相关。
肿瘤(癌症)患者之家