Background: Disease recurrence is the primary cause of death in patients with gastric cancer who have undergone complete surgical resection. No prognostic factors for recurrence, other than the Tumor, Node, and Metastasis stage, have been established. However, recurrence rates differ even within the same Tumor, Node, and Metastasis stage. Therefore, we aimed to develop a new prognostic confidence measure for gastric cancer recurrence and demonstrate its practical utility. Methods: This was a retrospective study based on the medical records of the Chungnam National University Hospital, Republic of Korea. We enrolled patients diagnosed with stage II/III gastric cancer who underwent complete surgical resection and adjuvant chemotherapy over the past 12 years. The association between seven variables, including the systemic inflammation response index (SIRI) and gastric cancer recurrence, was analyzed. Results: A total of 296 patients were enrolled in this study. Although other factors did not exhibit significant correlations, SIRI showed a significant positive correlation with gastric cancer recurrence risk, confirmed through Cox regression testing (hazard ratio, 1.231; 95% confidence interval, 1.04–1.45). Linear regression analysis revealed a significant association between higher SIRI values and shorter recurrence time (p= 0.044; β = −0.225). Conclusions: In this study, other than SIRI, effective prognostic factors related to gastric cancer recurrence were not verified, thus indicating SIRI as a potential independent prognostic factor.
背景：胃癌根治术后患者的主要死亡原因是疾病复发。目前除肿瘤-淋巴结-转移（TNM）分期外，尚未建立其他公认的复发预后因素。然而，即使在相同TNM分期患者中，复发率仍存在差异。因此，本研究旨在建立一种新的胃癌复发预后评估指标，并验证其临床应用价值。 方法：本研究为回顾性研究，基于韩国忠南国立大学医院的医疗记录数据。我们纳入了过去12年间诊断为II/III期胃癌、接受根治性手术切除及辅助化疗的患者。通过分析全身炎症反应指数（SIRI）等七项变量与胃癌复发的关联性进行评估。 结果：本研究共纳入296例患者。尽管其他因素未显示显著相关性，但Cox回归分析证实SIRI与胃癌复发风险呈显著正相关（风险比1.231；95%置信区间1.04-1.45）。线性回归分析显示，较高的SIRI值与较短的复发时间存在显著关联（p=0.044；β=-0.225）。 结论：本研究中，除SIRI外未验证到其他与胃癌复发相关的有效预后因素，表明SIRI可能作为独立的预后预测指标。
肿瘤(癌症)患者之家