Background: Malignant tumors of minor salivary glands (MGSTs) are rare and exhibit significant heterogeneity in terms of etiology, histology and prognosis. Methods: This retrospective analysis of 48 resected MGSTs employed Receiver Operating Characteristic (ROC) curves and logistic regression models to evaluate the association between the systemic inflammatory response index (SIRI), the systemic immuno-inflammation index (SII), the neutrophil/lymphocyte ratio (NLR), and the platelet/lymphocyte ratio (PLR) with overall survival (OS). Although these biomarkers showed some correlation with OS, none were statistically significant when considered individually. Results: Significant correlation was observed between the SIRI, SII, and NLR with overall survival (OS). Among these, SIRI was the most reliable predictor, with an area under the curve (AUC) of 0.713, 80% sensitivity, and 70% specificity. Conclusions: While these inflammatory biomarkers correlate with the prognosis and risk stratification of MGSTs, there is currently no clinical utility in decision making due to the lack of standardization and their limited application in clinical practice.
背景：小涎腺恶性肿瘤（MGSTs）较为罕见，且在病因学、组织学及预后方面表现出显著的异质性。方法：本研究对48例手术切除的MGSTs进行回顾性分析，采用受试者工作特征（ROC）曲线和逻辑回归模型，评估全身炎症反应指数（SIRI）、全身免疫炎症指数（SII）、中性粒细胞/淋巴细胞比值（NLR）及血小板/淋巴细胞比值（PLR）与总生存期（OS）之间的关联。尽管这些生物标志物与OS存在一定相关性，但单独考量时均未达到统计学显著性。结果：SIRI、SII和NLR与总生存期（OS）存在显著相关性。其中，SIRI是最可靠的预测指标，其曲线下面积（AUC）为0.713，敏感性为80%，特异性为70%。结论：虽然这些炎症生物标志物与MGSTs的预后及风险分层相关，但由于缺乏标准化且临床实践应用有限，目前尚不具备临床决策指导价值。
肿瘤(癌症)患者之家