As one of the leading components in the immune system, neutrophils in the tumor microenvironment (TME) have received considerable attention in recent years. The tumor-killing effects of neutrophils in a variety of tumors have been reported. However, the functions of neutrophils in tumors remain to be completely elucidated, and both anti-tumor and tumor-promotion activities have been reported. This review focuses on the characteristics of neutrophils and their mechanisms of action in the TME, with an emphasis on their anti-tumor activity, including reactive oxygen species (ROS)-induced tumor killing, cytotoxic T lymphocytes (CTLs)-induced tumor killing, trogocytosis, cytotoxic enzymes, and trained immunity. Furthermore, the possible targets and methods of tumor treatment regimens for neutrophils are explored, with the aim of exploring the use of neutrophils in the future as a potential anti-tumor treatment strategy.
作为免疫系统的主要成分之一，肿瘤微环境中的中性粒细胞近年来受到广泛关注。多项研究报道了中性粒细胞在多种肿瘤中的杀伤作用。然而，中性粒细胞在肿瘤中的功能尚未完全阐明，现有研究既报道了其抗肿瘤活性，也揭示了其促肿瘤作用。本综述重点探讨中性粒细胞的特征及其在肿瘤微环境中的作用机制，着重分析其抗肿瘤活性，包括活性氧介导的肿瘤杀伤、细胞毒性T淋巴细胞诱导的肿瘤杀伤、胞啃作用、细胞毒性酶以及训练免疫等方面。此外，本文还探讨了针对中性粒素的肿瘤治疗方案可能的作用靶点与方法，旨在为未来开发基于中性粒细胞的抗肿瘤治疗策略提供参考。
Role of Neutrophils in Anti-Tumor Activity: Characteristics and Mechanisms of Action
肿瘤(癌症)患者之家