文章：

术后放疗在局部头颈部黏膜黑色素瘤治疗中的作用

Role of Postoperative Radiotherapy in the Management of Localized Head and Neck Mucosal Melanoma

原文发布日期：10 April 2025

DOI: 10.3390/cancers17081284

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: To evaluate the role of postoperative radiotherapy (PORT) in the management of localized head and neck mucosal melanoma (HNMM). Methods: We retrospectively reviewed 33 patients who underwent surgery for localized HNMM between 2006 and 2023. PORT was delivered to affected anatomical structures, and elective nodal irradiation was not performed. Treatment outcomes, including local recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS), were analyzed. Results: After surgery, 14 patients (41.4%) received PORT. During follow-up, 87.9% of patients experienced recurrence, with local and distant failures being the most common. PORT significantly improved LRFS (p= 0.047) but did not impact PFS or OS. PORT (HR 0.14,p= 0.005) and resection margin status (HR 8.71,p< 0.001) were significantly associated with LRFS in multivariable analysis. Conclusions: PORT for localized HNMM improved local control. Regional recurrence was rare (one patient, 3.4%) even though ENI was not performed. PORT without ENI could improve clinical outcomes for localized HNMM.

摘要翻译： 

背景/目的：评估术后放疗（PORT）在局限性头颈部黏膜黑色素瘤（HNMM）治疗中的作用。方法：回顾性分析2006年至2023年间接受手术治疗的33例局限性HNMM患者。PORT针对受累解剖结构实施，未进行选择性淋巴结照射。分析治疗结果，包括局部无复发生存期（LRFS）、无进展生存期（PFS）和总生存期（OS）。结果：术后14例患者（41.4%）接受了PORT。随访期间，87.9%的患者出现复发，局部和远处复发最为常见。PORT显著改善了LRFS（p=0.047），但对PFS或OS无影响。多变量分析显示，PORT（HR 0.14，p=0.005）和手术切缘状态（HR 8.71，p<0.001）与LRFS显著相关。结论：PORT改善了局限性HNMM的局部控制。即使未进行ENI，区域复发罕见（1例，3.4%）。不联合ENI的PORT可能改善局限性HNMM的临床结局。

原文链接：

Role of Postoperative Radiotherapy in the Management of Localized Head and Neck Mucosal Melanoma