文章：

黑色素瘤患者前哨淋巴结阳性预测因素——液体活检、微小RNA与基因表达谱面板的作用

Predictive Factors for Sentinel Lymph Node Positivity in Melanoma Patients—The Role of Liquid Biopsy, MicroRNA and Gene Expression Profile Panels

原文发布日期：10 April 2025

DOI: 10.3390/cancers17081281

类型: Article

开放获取: 是

英文摘要：

The identification of predictive factors for sentinel lymph node (SLN) positivity in melanoma patients is crucial for accurate staging, prognosis, and personalized therapeutic decisions. This review synthesizes recent advancements in molecular and clinicopathological predictors, with a particular focus on liquid biopsy and gene expression profiling (GEP) tools. Emerging evidence highlights the significant role of miRNAs in melanoma progression, metastatic potential, and lymphatic spread. Clinicopathological factors such as Breslow thickness, ulceration, and mitotic rate remain critical, while GEP provides additional precision by uncovering tumor-specific molecular pathways. By integrating these tools, clinicians can improve risk stratification, reduce unnecessary procedures, and personalize management strategies.

摘要翻译： 

识别黑色素瘤患者前哨淋巴结（SLN）阳性的预测因素对于准确分期、预后评估及个体化治疗决策至关重要。本综述综合了分子与临床病理学预测因子的最新进展，特别聚焦于液体活检和基因表达谱（GEP）技术。新近证据表明，微小RNA在黑色素瘤进展、转移潜能及淋巴扩散中具有重要作用。Breslow厚度、溃疡形成和有丝分裂率等临床病理因素仍是关键指标，而GEP通过揭示肿瘤特异性分子通路提供了更精准的补充信息。整合这些工具可帮助临床医生优化风险分层、减少不必要的医疗操作，并实现个体化治疗策略。

原文链接：

Predictive Factors for Sentinel Lymph Node Positivity in Melanoma Patients—The Role of Liquid Biopsy, MicroRNA and Gene Expression Profile Panels