文章：

希腊女性高危型HPV基因型流行率与基因型分布：一项针对3500名女性的回顾性分析

Prevalence and Genotype Distribution of High-Risk HPV Genotypes Among Women in Greece: A Retrospective Analysis of 3500 Women

原文发布日期：9 April 2025

DOI: 10.3390/cancers17081267

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: Persistent infection with high-risk (HR) HPV genotypes is the main risk factor for the development of cervical cancer. The present analysis provides recent trends on HR-HPV infection rates and the distribution of HR-HPV genotypes among 3500 Greek women between 2021 and 2023.Methods: The detection of HR-HPVs and the specific identification of HPV16 and HPV18 were conducted using the Roche Cobas 4800 HPV assay. The genotyping of 12 other HR-HPV genotypes was performed through the Nested Multiplex PCR methodology (NMPCR).Results:The overall infection rate was 8.8% with the most prevalent HR-HPV genotype being HPV16 followed by HPV31, HPV66, HPV56, HPV51, HPV58, HPV45, HPV18, HPV68, HPV59, HPV52, HPV35, HPV39, and HPV33. Among HR-HPV-positive cases the prevalence of single, double, triple, and quadruple infections was 73.9%, 19.9%, 5.5%, and 0.7%, respectively. Age-specific analysis showed that the HR-HPV infection rate was higher in the age group of 31–35 years (25.5%) and it was estimated that multiple infections occur more often in younger women. Notably, the distribution of HR-HPV genotypes varies among different age groups. It is proposed that HPV16, HPV31, HPV56, and HPV66 may show an increased possibility of establishing long-term infections in Greek women over 36 years old.Conclusions:The high rates of specific HR-HPVs which are not included in the prophylactic vaccines underlines the significance of constant surveillance of circulating HPVs in the Greek population.

摘要翻译： 

背景/目的：高危型人乳头瘤病毒（HR-HPV）的持续感染是宫颈癌发生的主要风险因素。本研究分析了2021年至2023年间3500名希腊女性中HR-HPV感染率的最新趋势及HR-HPV基因型分布情况。方法：采用罗氏Cobas 4800 HPV检测方法进行HR-HPV筛查及HPV16、HPV18的特异性鉴定，其余12种HR-HPV基因型分型通过巢式多重PCR技术（NMPCR）完成。结果：总体感染率为8.8%，其中最常见的HR-HPV基因型为HPV16，其次依次为HPV31、HPV66、HPV56、HPV51、HPV58、HPV45、HPV18、HPV68、HPV59、HPV52、HPV35、HPV39和HPV33。在HR-HPV阳性病例中，单一感染、双重感染、三重感染及四重感染的占比分别为73.9%、19.9%、5.5%和0.7%。年龄分层分析显示，31-35岁年龄组的HR-HPV感染率最高（25.5%），且多重感染更常见于年轻女性。值得注意的是，不同年龄组的HR-HPV基因型分布存在差异。研究表明，HPV16、HPV31、HPV56和HPV66在36岁以上希腊女性中可能具有更高的长期感染风险。结论：当前预防性疫苗未覆盖的特定HR-HPV基因型在希腊人群中呈现较高感染率，这凸显了对希腊人群流行HPV毒株进行持续监测的重要性。

原文链接：

Prevalence and Genotype Distribution of High-Risk HPV Genotypes Among Women in Greece: A Retrospective Analysis of 3500 Women