Neoplastic cells are characterized by metabolic reprogramming, known as the Warburg effect, in which glucose metabolism is predominantly directed toward aerobic glycolysis, with reduced mitochondrial oxidative phosphorylation and increased lactate production even in the presence of oxygen. This phenomenon provides cancer cells with a proliferative advantage, allowing them to rapidly produce energy (in the form of ATP) and generate metabolic intermediates necessary for the biosynthesis of macromolecules essential for cell growth. It is important to understand the role of ion channels in the tumor context since they participate in various physiological processes and in the regulation of the tumor microenvironment. These changes may contribute to the development and transformation of cancer cells, as well as affect the communication between cells and the surrounding microenvironment, including impaired or altered expression and functionality of ion channels. Therefore, the aim of this review is to elucidate the impact of the tumor microenvironment on the electrical properties of the cellular membranes in several cancers as a possible therapeutic target.
肿瘤细胞的特征在于代谢重编程，即瓦博格效应，表现为即使在有氧条件下，葡萄糖代谢也主要转向有氧糖酵解，同时线粒体氧化磷酸化减弱、乳酸生成增加。这一现象为癌细胞提供了增殖优势，使其能够快速产生能量（以ATP形式）并生成细胞生长所需大分子生物合成所必需的代谢中间产物。理解离子通道在肿瘤背景下的作用至关重要，因为它们参与多种生理过程并调控肿瘤微环境。这些变化可能促进癌细胞的发育与转化，并影响细胞与周围微环境间的通讯，包括离子通道表达与功能的受损或改变。因此，本综述旨在阐明肿瘤微环境对多种癌症中细胞膜电学特性的影响，以探索其作为潜在治疗靶点的可能性。
Can the Tumor Microenvironment Alter Ion Channels? Unraveling Their Role in Cancer
肿瘤(癌症)患者之家