文章：

寡进展性非小细胞肺癌的治疗策略：消融性放疗综述

Treatment Approaches for Oligoprogressive Non-Small Cell Lung Cancer: A Review of Ablative Radiotherapy

原文发布日期：5 April 2025

DOI: 10.3390/cancers17071233

类型: Article

开放获取: 是

英文摘要：

Oligoprogressive disease refers to the setting of a prior or ongoing receipt of systemic therapy, with typically up to three metastatic areas having increased in size and/or avidity compared to the start of the systemic therapy. The role of local ablative therapy (LAT) including radiation has mostly been evaluated in the oligometastatic setting with limited data in oligoprogression. A similar principle of using ablative radiation in the oligometastatic setting may be applied to consolidative therapy for oligoprogressive disease. If systemic therapy can control the majority of the disease, and a few areas of therapy-resistant clones continue to proliferate, then potentially controlling those few resistant clones while maintaining systemic control may be beneficial. Doing so may also extend the duration of benefit of the systemic therapy and reserve next systemic line options at a later point, and potentially improve progression free survival (PFS). Here, we review the current data evaluating the role of radiation in oligoprogressive non-small cell lung cancer (NSCLC) and ongoing trials.

摘要翻译： 

寡进展性疾病是指在接受或正在接受全身性治疗的情况下，通常最多三个转移灶相较于全身治疗开始时出现体积增大和/或代谢活性增强。局部消融治疗（包括放疗）的作用主要在寡转移背景下得到评估，而在寡进展背景下的数据有限。在寡转移背景下应用消融性放疗的类似原则，可延伸至寡进展性疾病的巩固治疗。若全身治疗能够控制大部分病灶，而少数耐药克隆区域持续增殖，则在维持全身控制的同时对这些少数耐药克隆进行局部控制可能具有临床获益。这种做法还可能延长全身治疗的获益持续时间，为后续全身治疗方案保留选择空间，并有望改善无进展生存期。本文综述了当前评估放疗在寡进展性非小细胞肺癌中作用的研究数据及正在进行中的临床试验。

原文链接：

Treatment Approaches for Oligoprogressive Non-Small Cell Lung Cancer: A Review of Ablative Radiotherapy