Background: Squamous cell carcinoma (SCC) presents a significant challenge in dermatological pathology, necessitating comprehensive insights for effective management. This review highlights SCC’s broad aspects and focuses particularly on carcinoma cuniculatum (CC), a rare variant that warrants special attention due to its unique diagnostic and therapeutic challenges. Methods: We conducted a narrative review of current literature on SCC and CC, supplemented by illustrative clinical case presentations. The analysis emphasized epidemiology, pathogenesis, clinical presentation, diagnostic pitfalls, and treatment modalities. Results: The key findings from our analysis indicate that CC, although locally aggressive, exhibits a lower metastatic potential and requires distinct management strategies, primarily surgical, due to its poor responsiveness to radiotherapy. Conclusions: The review also includes illustrative clinical cases to highlight the diverse presentations and underscore the necessity for multidisciplinary approaches and heightened clinical vigilance in diagnosing and managing CC. By consolidating current knowledge and clinical experiences, this review aims to enhance awareness, facilitate early recognition, and optimize therapeutic strategies for SCC, particularly CC, thereby improving patient outcomes and prognosis.
背景：鳞状细胞癌（SCC）是皮肤病理学领域的一大挑战，需要全面深入的认识以实现有效管理。本综述系统阐述了SCC的广泛特征，并特别聚焦于疣状癌（CC）这一罕见亚型。由于其独特的诊断与治疗难点，CC值得临床特别关注。方法：我们对当前关于SCC与CC的文献进行了叙述性综述，并结合典型临床病例进行阐述。分析重点涵盖流行病学、发病机制、临床表现、诊断误区及治疗模式。结果：分析表明，CC虽具有局部侵袭性，但转移潜能较低；由于其对放射治疗反应不佳，主要需采用以手术为主的特殊治疗策略。结论：本综述通过典型临床病例展示了CC多样化的临床表现，强调在诊断与治疗过程中需采取多学科协作模式并保持高度临床警惕性。通过整合现有知识与临床经验，本综述旨在提升临床认知、促进早期识别，并优化SCC（特别是CC）的治疗策略，从而改善患者预后。
Squamous Cell Carcinoma and Its Rare Variant, Carcinoma Cuniculatum: Insights and Case Studies
肿瘤(癌症)患者之家