Glioblastoma (GBM) remains a challenging cancer to treat with limited effective therapies. Standard treatments, including surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy, offer marginal survival benefits but are often limited by side effects and drug resistance. Temozolomide is the most commonly used chemotherapy; however, resistance and lack of efficacy in recurrent GBM hinder its success. Tumor treating fields (TTFields), a novel non-invasive modality that utilizes alternating electric fields, have recently emerged as a promising treatment for GBM. TTFields work by disrupting the function of the mitotic spindle and inducing apoptosis in cancer cells. They can be especially effective when combined with other therapies. TTFields enhance drug delivery when paired with chemotherapy by increasing the permeability of the blood–brain barrier and cell membranes, leading to more effective tumor inhibition. Similarly, TTFields increase cancer cell sensitivity to radiation therapy and improve the efficacy of targeted therapies, such as sorafenib and immunotherapy, particularly in extra-cranial tumors. The Optune device, the primary medical device for TTFields’ delivery, offers a convenient and versatile treatment option, allowing remote care and exhibiting fewer adverse effects. This review discusses the potential of TTFields as a valuable addition to GBM treatment, particularly in combination therapies, and highlights the device’s clinical applications.
胶质母细胞瘤（GBM）的治疗仍面临巨大挑战，现有有效疗法有限。手术、放疗、化疗、靶向治疗及免疫治疗等标准治疗方案虽能带来有限的生存获益，但常受副作用和耐药性制约。替莫唑胺是最常用的化疗药物，然而其在复发性GBM中的耐药性和疗效不足限制了其应用。肿瘤治疗电场（TTFields）作为一种新型非侵入性治疗手段，通过交变电场发挥作用，近年来已成为GBM治疗的新希望。TTFields通过破坏有丝分裂纺锤体功能并诱导癌细胞凋亡发挥作用，尤其在与其它疗法联用时效果显著。当与化疗联用时，TTFields可通过增强血脑屏障和细胞膜通透性提高药物递送效率，从而实现更有效的肿瘤抑制。同样地，TTFields能增强癌细胞对放疗的敏感性，并提升索拉非尼等靶向治疗及免疫治疗（尤其对颅外肿瘤）的疗效。作为实施TTFields治疗的主要医疗设备，Optune装置提供了便捷灵活的治疗选择，支持远程监护且不良反应较少。本综述探讨了TTFields作为GBM治疗重要补充手段（尤其在联合治疗中）的潜力，并重点介绍了该装置的临床应用。
Tumor Treating Fields and Combination Therapy in Management of Brain Oncology
肿瘤(癌症)患者之家