Objectives: Inflammatory fibroid polyps, also known as Vanek’s tumors, are rare benign lesions of the gastrointestinal tract. Although the exact cause remains unclear, several theories suggest an association with inflammatory processes and genetic factors. This study aims to present the largest cohort of inflammatory fibroid polyp cases to date, analyzing their clinical presentation, diagnostic methods, and treatment approaches. Materials and methods: A retrospective multicentric analysis was conducted on 67 patients diagnosed with inflammatory fibroid polyps between 2013 and 2023 across four hospitals. Clinical data regarding tumor location, size, symptoms, and treatment were collected. Non-parametric statistical tests, including the chi-square test, Cramér’s V coefficient, and the Mann–Whitney U test, were used to identify association between tumor characteristics, location, and treatment outcomes. Results: The cohort included 67 patients (58.2% female, median age 60 years). The stomach was the most common tumor site (47.8%), followed by the colon (32.8%), and small intestine (10.4%). The majority of patients (73.1%) were asymptomatic, while 9% experienced intestinal obstruction, all of which were located in the small intestine. Endoscopic resection was successful in 77.6% of cases, but surgical intervention was more frequently required for tumors in the small intestine. A significant association was found between larger tumor size, emergency presentation, intestinal location, and the need for surgery. Conclusions: Inflammatory fibroid polyps are commonly managed with endoscopic resection, particularly in gastric and colonic locations. However, small intestinal tumors more often need surgical treatment, especially when presenting with complications like intestinal obstruction.
目的：炎性纤维性息肉，亦称Vanek肿瘤，是消化道罕见的良性病变。尽管确切病因尚未明确，但多种理论提示其与炎症过程及遗传因素相关。本研究旨在呈现迄今最大规模的炎性纤维性息肉病例队列，分析其临床表现、诊断方法及治疗策略。材料与方法：对2013年至2023年间四家医院确诊的67例炎性纤维性息肉患者进行回顾性多中心分析，收集肿瘤位置、大小、症状及治疗等临床数据。采用卡方检验、Cramér's V系数及Mann-Whitney U检验等非参数统计方法，分析肿瘤特征、部位与治疗结果之间的关联性。结果：队列共纳入67例患者（女性占58.2%，中位年龄60岁）。胃是最常见的发病部位（47.8%），其次为结肠（32.8%）和小肠（10.4%）。多数患者（73.1%）无症状，9%出现肠梗阻症状且均位于小肠。内镜下切除术成功率为77.6%，但小肠肿瘤更常需外科干预。研究发现肿瘤体积较大、急诊就诊、肠道定位与手术必要性存在显著关联。结论：内镜下切除术是炎性纤维性息肉的主要治疗方式，尤其适用于胃与结肠病变。然而小肠肿瘤更常需外科治疗，特别是在出现肠梗阻等并发症时。
Inflammatory Fibroid Polyp (Vanek’s Tumor): A Retrospective Multicentric Analysis of 67 Cases
肿瘤(癌症)患者之家