文章：

增殖性疣状白斑的恶性转化：这些鳞状细胞癌的临床口腔特征描述

Malignant Transformation of Proliferative Verrucous Leukoplakia: A Description of the Clinical Oral Characteristics of These Squamous Cell Carcinomas

原文发布日期：1 April 2025

DOI: 10.3390/cancers17071199

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: Proliferative verrucous leukoplakia (PVL) is an oral disorder with the greatest degree of malignant transformation. However, it is relatively rare. This study compared the clinical characteristics of patients with oral squamous cell carcinoma (OSCC) who had and had not been previously diagnosed with PVL.Methods: This case control study compared the clinical characteristics of patients classified as early (T1 and T2) or advanced (T3 and T4) OSCC according to the T size of the Tumor, Node, Metastasis (TNM) classification, including age, gender, location, and clinical type of oral squamous cell carcinoma. The analysis involved 140 patients. Group 1: 50 OSCC patients with PVL (OSCC-PVL) and Group 2: 90 OSCC patients without PVL (OSCC-noPVL).Results: The patients with OSCC-PVL were younger than those with OSCC-noPVL, but this did not reach statistical significance. Regarding patient gender, those with OSCC-PVL were much more frequently female (70%), while OSCC-noPVL was more prevalent in men (65.5%) (p< 0.01). There were also significant differences in the oral locations between the two groups: the gingiva was most prevalent in OSCC-PVL and the tongue in OSCC-noPVL. Erythroleukoplastic forms were significantly more common in OSCC-PVL (30% vs. 7.7%), while ulcerated forms were more frequent in OSCC-noPVL (63.3% vs. 42%). Finally, early T stages were much more prevalent in our patients with OSCC-PVL.Conclusions: We found that OSCC preceded by PVL was much more frequent in women, had less aggressive clinical forms, and had significantly more frequent early T stages than in OSCC-noPVL.

摘要翻译： 

背景/目的：增殖性疣状白斑（PVL）是口腔疾病中恶性转化风险最高的一种，但其相对罕见。本研究比较了既往确诊PVL与未确诊PVL的口腔鳞状细胞癌（OSCC）患者的临床特征差异。方法：本病例对照研究根据肿瘤-淋巴结-转移（TNM）分期中的T分期，将患者分为早期（T1和T2）或晚期（T3和T4）OSCC，比较其临床特征，包括年龄、性别、发病部位及口腔鳞癌的临床类型。研究共纳入140例患者：第一组为50例合并PVL的OSCC患者（OSCC-PVL），第二组为90例不合并PVL的OSCC患者（OSCC-noPVL）。结果：OSCC-PVL患者较OSCC-noPVL患者更为年轻，但差异未达到统计学显著性。在性别分布方面，OSCC-PVL患者以女性为主（70%），而OSCC-noPVL患者以男性居多（65.5%）（p<0.01）。两组在口腔发病部位上亦存在显著差异：OSCC-PVL最常见于牙龈，而OSCC-noPVL最常见于舌部。红白斑型病变在OSCC-PVL中显著更常见（30% vs. 7.7%），而溃疡型病变在OSCC-noPVL中更普遍（63.3% vs. 42%）。最后，早期T分期在OSCC-PVL患者中占比显著更高。结论：研究发现，与OSCC-noPVL相比，继发于PVL的OSCC更多见于女性，其临床类型侵袭性较低，且早期T分期比例显著更高。

原文链接：

Malignant Transformation of Proliferative Verrucous Leukoplakia: A Description of the Clinical Oral Characteristics of These Squamous Cell Carcinomas