Background: Falx and convexity meningiomas can compress surrounding brain structures, frequently resulting in epileptic seizures, which adversely impact the quality of life (QoL) of affected patients. This study aimed to assess postoperative QoL in patients with documented perioperative seizures associated with falx and convexity meningiomas. Methods: The Quality of Life in Epilepsy Inventory-31 (QOLIE-31) was administered to patients who underwent surgery for falx/convexity meningiomas and experienced perioperative seizures. Seizures were defined as those occurring within 30 days pre- or post-surgery. Results: A total of 77 patients responded to the questionnaire, of whom 44 were female and 33 were male. Multivariable analysis showed that falx meningioma was associated with a lower QOLIE-31 score (OR = 4.02, 95% CI: 1.14–14.18,p= 0.03). Furthermore, the presence of peritumoral edema was also associated with lower QOLIE-31 scores (OR = 3.89, 95% CI: 1.04–14.47,p= 0.043). Conclusions: This study demonstrates that perioperative seizures in patients with falx meningiomas significantly impact postoperative quality of life. The presence of peritumoral edema was also associated with poorer QoL outcomes. These findings underscore the importance of targeted management strategies to to improve QoL in meningioma patients experiencing seizures.
背景：大脑镰和凸面脑膜瘤可压迫周围脑组织，常引发癫痫发作，严重影响患者的生活质量。本研究旨在评估伴有围手术期癫痫发作的大脑镰和凸面脑膜瘤患者术后的生活质量。方法：对因大脑镰/凸面脑膜瘤接受手术且经历围手术期癫痫发作的患者，采用癫痫患者生活质量量表-31进行评估。癫痫发作定义为手术前后30天内发生的发作。结果：共有77名患者完成问卷，其中女性44例，男性33例。多变量分析显示，大脑镰脑膜瘤与较低的QOLIE-31评分相关（OR = 4.02，95% CI：1.14–14.18，p = 0.03）。此外，瘤周水肿的存在也与较低的QOLIE-31评分相关（OR = 3.89，95% CI：1.04–14.47，p = 0.043）。结论：本研究表明，大脑镰脑膜瘤患者的围手术期癫痫发作显著影响术后生活质量。瘤周水肿的存在也与较差的生活质量结局相关。这些发现强调了采取针对性管理策略以改善伴发癫痫的脑膜瘤患者生活质量的重要性。
肿瘤(癌症)患者之家