Urogenital cancer is very common in the male population of Western countries, a problem of major concern for public health systems, and a frequent test subject for oncological research. In this narrative, we identify the main hot topics for clinics and the basic science of urological cancer in the last few years (from 2021 onwards), considering the information given in the abstracts of almost 300 original articles published in outstanding journals of pathology, urology, and basic science. Once defined, for the top ten list of hot topics (the 2022 WHO update on the classification of urinary and male genital tumors, new entities in kidney cancer, urinary cancer-omics, update on the Gleason grading system, targeted therapies and other novel therapies in renal cancer, news on non-muscle invasive urothelial carcinoma, artificial intelligence in urologic cancer, intratumor heterogeneity influence in therapeutic failures in urologic neoplasms, intratumor microbiome and its influence in urologic tumor aggressiveness, and ecological principles and mathematics applied to urogenital cancer study), each issue is independently reviewed in an attempt to put together the most relevant updates and/or useful features accompanied by selected illustrations. This review article addresses some of the most interesting and current hot spots in urogenital basic cancer research and clinics and is mainly aimed toward clinicians, including pathologists, urologists, and oncologists. Readers are invited to explore each topic for further, more detailed information, in addition to the references provided.
泌尿生殖系统肿瘤在西方国家男性群体中极为常见，已成为公共卫生系统重点关注的问题，也是肿瘤学研究中的常见课题。本文基于近300篇发表于病理学、泌尿外科学及基础科学领域权威期刊的原始研究摘要，梳理了近年来（2021年起）泌尿系统肿瘤在临床诊疗与基础研究方面的核心热点议题。通过系统分析，我们确定了十大热点主题（2022年WHO泌尿及男性生殖系统肿瘤分类更新、肾癌新分型、泌尿系统肿瘤组学研究、格里森分级系统更新、肾癌靶向治疗及其他新型疗法、非肌层浸润性尿路上皮癌新进展、人工智能在泌尿肿瘤中的应用、肿瘤内异质性对泌尿肿瘤治疗失败的影响、肿瘤内微生物组对泌尿肿瘤侵袭性的影响、生态学原理与数学方法在泌尿生殖系统肿瘤研究中的应用），并对每个主题进行独立评述，整合最具相关性的更新内容和/或实用特征，辅以精选例证说明。本综述聚焦当前泌尿生殖系统肿瘤基础研究与临床实践中最具价值的前沿热点，主要面向临床工作者（包括病理学家、泌尿外科医师及肿瘤科医师）。除文末参考文献外，建议读者对各主题进行延伸探索以获取更详尽信息。
肿瘤(癌症)患者之家