Background/Objectives: Early-onset cancer is an emerging global health concern, including in the United States. However, data on early-onset liver and intrahepatic bile duct cancer remain limited. This study aims to fill this gap by analyzing trends in early-onset liver and intrahepatic bile duct cancer in the United States over the past two decades.Methods: This study used National Childhood Cancer Registry data to examine temporal trends in early-onset liver and intrahepatic bile duct cancer in the United States. The analysis involved estimating age-adjusted incidence rates of early-onset liver and intrahepatic bile duct cancer, stratified by histological type, ethnicity, and sex.Results:In 2021, the age-adjusted incidence rate of early-onset liver and intrahepatic bile duct cancer was estimated at 0.53 per 100,000 population (95% Confidence Interval [CI]: 0.48–0.59). From 2001 to 2021, the age-adjusted incidence rate showed a significant annual percent change (APC) of 1.35% (95% CI: 0.87–1.83%). When stratified by sex, the age-adjusted incidence rate in females increased significantly (APC: 3.07%, 95% CI: 2.26–3.87%) while remaining stable in males. Among racial and ethnic groups, non-Hispanic American Indian and Alaska Native (AIAN) individuals had the highest age-adjusted incidence rate, recorded at 2.67 per 100,000 population (95% CI: 0.95–5.85). By histological type, hepatic carcinoma had the highest age-adjusted incidence rate, significantly increasing over time (APC: 1.47%, 95% CI: 0.96–1.99%). In contrast, the incidence rates for hepatoblastoma and unspecified hepatic tumors remained stable between 2001 and 2021.Conclusions: Our study identified an increasing incidence of early-onset liver and intrahepatic bile duct cancer in the United States, primarily driven by cases in females and hepatic carcinoma.
背景/目的：早发性癌症已成为全球范围内日益严峻的健康问题，美国亦不例外。然而，目前关于早发性肝癌及肝内胆管癌的数据仍较为有限。本研究旨在通过分析美国近二十年来早发性肝癌及肝内胆管癌的发病趋势，填补这一研究空白。 方法：本研究利用美国国家儿童癌症登记数据，系统分析了美国早发性肝癌及肝内胆管癌的时间趋势。通过计算经年龄调整的发病率，并按组织学类型、种族/民族及性别进行分层分析。 结果：2021年，早发性肝癌及肝内胆管癌的年龄调整发病率为0.53/10万（95%置信区间[CI]：0.48–0.59）。2001年至2021年间，年龄调整发病率呈现显著的年均百分比变化（APC）为1.35%（95% CI：0.87–1.83%）。按性别分层显示，女性年龄调整发病率显著上升（APC：3.07%，95% CI：2.26–3.87%），而男性发病率保持稳定。在种族/民族分组中，非西班牙裔美国印第安人和阿拉斯加原住民（AIAN）的年龄调整发病率最高，达2.67/10万（95% CI：0.95–5.85）。按组织学类型分析，肝细胞癌的年龄调整发病率最高，且随时间推移显著增长（APC：1.47%，95% CI：0.96–1.99%）。相比之下，肝母细胞瘤和未特指肝肿瘤的发病率在2001年至2021年间保持稳定。 结论：本研究发现美国早发性肝癌及肝内胆管癌发病率呈上升趋势，这一变化主要由女性病例和肝细胞癌的增长所驱动。
肿瘤(癌症)患者之家