Background/Objectives: To evaluate the prognostic value of easily obtainable biomarkers for patients undergoing percutaneous microwave ablation (MWA) for colorectal liver metastases (CLMs). Prior studies showed that simple biomarkers, such as the lymphocyte-to-monocyte ratio (LMR), albumin-to-globulin ratio (AGR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR), as well as cancer-specific markers, like carcinoembryonic antigen (CEA), might have a prognostic role in various malignancies; however, none of these were assessed in patients undergoing MWA for CLMs.Methods: Based on the simple laboratory results, which were determined prior to the ablation, several biomarkers, including the LMR, AGR, PLR, and NLR, were calculated. The log-rank test’s optimal cutoff points for continuous variables were determined. Subsequently, univariable and multivariable Cox regression models were utilized to determine the association between various features and overall survival (OS).Results: This study included 57 CLM patients with a mean age of 63 ± 12.5 years at the time of ablation with a mean follow up of 30.9 months. The univariable model demonstrated that a high level of CEA (cutoff: 29.1 ng/mL; HR: 3.70) and a high LMR (cutoff: 5.32; HR: 4.05) were related to worse OS, whereas a high NLR (cutoff: 2.05; HR: 0.31) and primary left-sided colon cancer (HR: 0.36) were positive prognostic factors. The multivariable regression model confirmed these findings, with the exception of the LMR, which was no longer significantly associated with OS.Conclusions: This study demonstrates the feasibility of overall survival prediction and thus patient stratification based on easily obtainable biomarkers and clinicopathological features in CLM patients undergoing MWA.
背景/目的：评估易于获取的生物标志物对接受经皮微波消融（MWA）治疗的结直肠肝转移（CLM）患者的预后价值。先前研究表明，淋巴细胞与单核细胞比值（LMR）、白蛋白与球蛋白比值（AGR）、血小板与淋巴细胞比值（PLR）及中性粒细胞与淋巴细胞比值（NLR）等简易生物标志物，以及癌胚抗原（CEA）等肿瘤特异性标志物可能对多种恶性肿瘤具有预后意义，但这些指标在接受MWA治疗的CLM患者中尚未得到系统评估。 方法：基于消融前获取的基础实验室检测结果，计算LMR、AGR、PLR和NLR等生物标志物。通过时序检验确定连续变量的最佳截断值，随后采用单变量和多变量Cox回归模型分析各特征与总生存期（OS）的关联性。 结果：本研究纳入57例CLM患者，消融时平均年龄为63±12.5岁，平均随访时间30.9个月。单变量分析显示，高水平CEA（截断值：29.1 ng/mL；风险比：3.70）与高LMR（截断值：5.32；风险比：4.05）与较差的OS相关，而高NLR（截断值：2.05；风险比：0.31）及左半结肠原发癌（风险比：0.36）则为积极预后因素。多变量回归模型验证了上述发现，但LMR与OS的关联性不再具有统计学意义。 结论：本研究证实基于易获取的生物标志物和临床病理特征，对接受MWA治疗的CLM患者进行总生存期预测及风险分层具有可行性。
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