Lymphoblastic leukemia/lymphoma, a neoplasm of precursor B or T lineage lymphoid cells, usually involves the bone marrow and peripheral blood, and may involve nodal and/or extranodal sites. The diagnosis is based on morphologic assessment, immunophenotypic analysis, usually by flow cytometry, and genetic analysis, including cytogenetics and FISH analysis, as well as molecular diagnostic analysis. This review will focus on the flow cytometric immunophenotypic findings in B- and T-lymphoblastic leukemia/lymphoma, which include expressions of early B or T cell markers, low-level expressions of CD45, as well as expressions of terminal deoxynucleotidyl transferase (TdT), and, in many cases, stem/progenitor cell marker CD34.
淋巴母细胞白血病/淋巴瘤是一种起源于前体B或T系淋巴细胞的肿瘤，通常累及骨髓和外周血，并可侵犯淋巴结和/或结外部位。其诊断依赖于形态学评估、免疫表型分析（通常采用流式细胞术）以及遗传学分析（包括细胞遗传学和荧光原位杂交分析）与分子诊断分析。本综述将重点探讨B系和T系淋巴母细胞白血病/淋巴瘤的流式细胞免疫表型特征，包括早期B或T细胞标志物的表达、CD45的低水平表达、末端脱氧核苷酸转移酶（TdT）的表达，以及在多数病例中干细胞/祖细胞标志物CD34的表达。
The Flow Cytometric Evaluation of B- and T-Lymphoblastic Leukemia/Lymphoma
肿瘤(癌症)患者之家