文章：

乳腺腺样囊性癌：叙述性综述及治疗进展

Adenoid Cystic Carcinoma of the Breast: A Narrative Review and Update on Management

原文发布日期：23 March 2025

DOI: 10.3390/cancers17071079

类型: Article

开放获取: 是

英文摘要：

Rare breast malignancies represent a challenge for treatment decision making given the lack of evidence-based guidelines. As a particularly uncommon tumor, adenoid cystic carcinomas are especially challenging. Although, histopathologically, they share the same tumor molecular profile as hormone receptor-negative and HER2 nonamplified carcinomas with aggressive physiology, adenoid cystic carcinomas generally have a favorable prognosis. Thus, there is evidence to suggest that more aggressive treatment regimens may not provide better therapeutic effects. In this review, we discuss ACCB with the goal of highlighting pathophysiology, clinical features, and treatment strategies. Existing data support consideration for adjuvant radiation with the omission of axillary staging and systemic therapies.

摘要翻译： 

罕见乳腺恶性肿瘤由于缺乏循证指南，在治疗决策上构成挑战。其中腺样囊性癌作为一种尤为罕见的肿瘤类型，其临床处理尤为复杂。尽管在组织病理学上，这类肿瘤与激素受体阴性、HER2非扩增且具有侵袭性生物学特征的癌种具有相同的分子表达谱，但腺样囊性癌通常预后良好。因此，现有证据表明更积极的治疗方案可能无法带来更好的治疗效果。本综述旨在通过探讨乳腺腺样囊性癌，系统阐述其病理生理机制、临床特征及治疗策略。现有数据支持在治疗中考虑辅助放疗，同时可省略腋窝分期及全身性系统治疗。

原文链接：

Adenoid Cystic Carcinoma of the Breast: A Narrative Review and Update on Management