Background: Adolescent and young adult (AYA) cancer survivors have unique needs, yet few tailored rehabilitation programs exist. CaRE-AYA is an 8-week multidimensional rehabilitation program for AYAs that targets impairments, activity limitations and participation restrictions and comprises an individualized exercise prescription and weekly group-based exercise and self-management education. Methods: We conducted a single-arm multi-method pragmatic feasibility study evaluating CaRE-AYA’s feasibility, acceptability, and safety (primary outcomes) and assessed disability, physical functioning, mental health, and social functioning at baseline (T0), immediately post-intervention (T1), and 3 months post-intervention (T2). Results: Twenty-five participants (median age: 32.8, 76% female) were enrolled. Participation (60%), retention (84% at T1, 72% at T2), and program adherence (76% for education classes, 74% for exercise classes) supported feasibility. Qualitative interviews (n= 9) supported strong perceptions of feasibility and acceptability. No serious adverse events (≥grade 3) attributed to CaRE-AYA occurred. Conclusions: The results suggest CaRE-AYA is feasible, acceptable, and safe. A randomized controlled trial is needed to determine the effectiveness.
背景：青少年与年轻成人癌症幸存者具有独特需求，但目前鲜有针对该群体的定制化康复方案。CaRE-AYA是一项为期八周的多维度康复计划，针对该群体功能障碍、活动受限及参与限制等问题，包含个体化运动处方以及每周团体运动与自我管理教育课程。方法：本研究采用单臂混合方法实用性可行性研究设计，评估CaRE-AYA的可行性、可接受性与安全性（主要结局指标），并在基线（T0）、干预结束时（T1）及干预后3个月（T2）三个时间点评估功能障碍、身体机能、心理健康及社会功能。结果：共纳入25名参与者（中位年龄32.8岁，女性占76%）。参与率（60%）、保留率（T1时84%，T2时72%）及方案依从性（教育课程76%，运动课程74%）数据支持方案可行性。质性访谈（n=9）结果显示参与者对方案的可行性与可接受性持积极态度。研究期间未发生与CaRE-AYA相关的严重不良事件（≥3级）。结论：研究结果表明CaRE-AYA方案具有可行性、可接受性与安全性。未来需通过随机对照试验验证其有效性。
肿瘤(癌症)患者之家