文章：

副肿瘤性皮肤综合征早期诊断在癌症检测中的重要性及挑战——综述

The Importance and Challenges of Early Diagnosis of Paraneoplastic Skin Syndromes in Cancer Detection—A Review

原文发布日期：21 March 2025

DOI: 10.3390/cancers17071053

类型: Article

开放获取: 是

英文摘要：

Skin paraneoplastic syndromes (SPNSs) are a group of disorders that arise as a consequence of cancer but are not directly related to the tumor mass itself. This review aims to provide a comprehensive overview of these syndromes, encompassing their pathophysiology, clinical features, diagnostic approaches, differential diagnosis, and management strategies. These syndromes, which include conditions such as Bazex syndrome, acanthosis nigricans, dermatomyositis, and necrolytic migratory erythema often manifest prior to or concurrently with a cancer diagnosis, serving as potential early warning signs of underlying malignancies. This review delves into the spectrum of SPNSs and their associations with specific cancer types. Special emphasis is placed on the critical role of dermatologists and oncologists in identifying these skin manifestations as potential markers of malignancy. By raising awareness of SPNSs, this paper highlights the pivotal importance of prompt recognition and intervention in reducing cancer-related mortality.

摘要翻译： 

皮肤副肿瘤综合征是一类由癌症引发，但与肿瘤本身无直接关联的疾病。本文旨在系统综述此类综合征的病理生理机制、临床表现、诊断方法、鉴别诊断及治疗策略。包括巴泽克斯综合征、黑棘皮病、皮肌炎、坏死松解性游走性红斑等在内的这类综合征，常在癌症确诊前或同时出现，可能成为潜在恶性肿瘤的早期预警信号。本文深入探讨了皮肤副肿瘤综合征的疾病谱及其与特定癌症类型的关联，特别强调了皮肤科医生与肿瘤科医生在识别这些皮肤表现作为潜在恶性肿瘤标志物中的关键作用。通过提升对皮肤副肿瘤综合征的认知，本文揭示了及时识别与干预对于降低癌症相关死亡率的重要意义。

原文链接：

The Importance and Challenges of Early Diagnosis of Paraneoplastic Skin Syndromes in Cancer Detection—A Review