Background/Objectives: Prostate cancer is one of the most prevalent cancers among men, with a significant proportion progressing to metastatic disease. Traditional treatments for metastatic prostate cancer have primarily been palliative, focusing on symptom relief. However, recent advances in radiotherapy have shown promise in improving outcomes for these patients.Methods: This study presents a modern treatment plan for extensive metastatic prostate cancer. Pre-treatment imaging revealed extensive lymph node metastases and high metabolic activity in the prostate. The treatment regimen included bicalutamide, androgen deprivation therapy with leuprorelin, and six cycles of docetaxel chemotherapy, followed by a targeted radiotherapy regimen aimed at both the primary tumor and metastatic lymph nodes.Results: Following the comprehensive radiotherapy regimen, the patient’s PSA level dropped below the edge of detection, indicating complete biochemical remission. Follow-up imaging and clinical assessments confirmed the absence of active metastatic sites.Conclusions: The findings support the integration of radiotherapy into comprehensive treatment plans for metastatic prostate cancer, demonstrating that radiotherapy can achieve complete remission even in patients with extensive metastatic disease. This suggests a need for re-evaluating traditional approaches and exploring more personalized, multimodal treatment strategies. Enhanced imaging techniques, such as PET/PSMA scans, play a crucial role in accurately targeting metastatic sites, enabling more effective and individualized treatment.
背景/目的：前列腺癌是男性最常见的恶性肿瘤之一，其中相当一部分会进展为转移性疾病。传统上对转移性前列腺癌的治疗主要为姑息性，侧重于症状缓解。然而，近期放射治疗领域的进展为改善这类患者的预后带来了希望。 方法：本研究提出了一种针对广泛转移性前列腺癌的现代治疗方案。治疗前影像学检查显示患者存在广泛的淋巴结转移，且前列腺代谢活性增高。治疗方案包括比卡鲁胺、亮丙瑞林内分泌治疗及六个周期的多西他赛化疗，随后实施针对原发灶和转移淋巴结的靶向放射治疗方案。 结果：完成综合放射治疗方案后，患者前列腺特异性抗原水平降至检测下限以下，表明达到完全生化缓解。后续影像学及临床评估证实已无活动性转移病灶。 结论：研究结果支持将放射治疗整合到转移性前列腺癌的综合治疗方案中，证明即使在广泛转移的患者中，放射治疗也能实现完全缓解。这表明有必要重新评估传统治疗模式，探索更具个性化、多模式的治疗策略。PET/PSMA等先进影像技术在精确定位转移病灶方面发挥着关键作用，有助于实现更有效、个体化的治疗。
The Role and Potential of Modern Radiotherapy in the Treatment of Metastatic Prostate Cancer
肿瘤(癌症)患者之家