Background/Objectives: Endometrial cancer (EC) is a prevalent gynecological malignancy with an increasing incidence, particularly in developed countries. Recent research has demonstrated the significant involvement of gut and endometrial microbiomes in the pathogenesis and progression of EC. This review provides a comprehensive overview of the existing knowledge on the interactions between these microbial communities and their influence on EC.Methodology: A literature review was conducted using electronic databases including Google Scholar, Scopus, and PUBMED, covering the period from 2017 to 2024. The following keywords were used for the literature search: (1) gut microbiome and endometrial cancer, (2) endometrium microbiome and endometrial cancer, and (3) endometrial cancer and microbial dysbiosis. The selected articles were chosen based on inclusion and exclusion criteria. Scale for Assessment of Narrative Review Articles (SANRA) was used for evaluating and assessing the quality of articles.Results: The gut microbiome modulates systemic inflammation, immune responses, and estrogen metabolism, all of which are crucial factors in EC development. Dysbiosis is an imbalance in the composition of microbes that can cause chronic inflammation and hormonal imbalances, which can contribute to the EC. Similarly, the endometrial microbiome, while less extensively studied, has been implicated in EC through mechanisms involving local immune modulation and the production of harmful metabolites. Probiotics, prebiotics, fecal microbiota transplantation (FMT), and personalized microbiota-based therapies can be used as clinical interventions for EC management. This review emphasizes the need for further research to explore the gut–endometrium axis and its potential for innovative therapeutic approaches. Understanding these complex interactions will become a novel strategy to prevent and treat EC, ultimately enhancing patient outcomes.
背景/目的：子宫内膜癌是一种常见的妇科恶性肿瘤，其发病率呈上升趋势，在发达国家尤为明显。近期研究表明，肠道微生物组和子宫内膜微生物组在子宫内膜癌的发病机制及进展中起着重要作用。本综述全面概述了关于这些微生物群落之间相互作用及其对子宫内膜癌影响的现有知识。 方法：通过Google Scholar、Scopus和PUBMED等电子数据库对2017年至2024年的文献进行检索。文献检索采用以下关键词：(1) 肠道微生物组与子宫内膜癌，(2) 子宫内膜微生物组与子宫内膜癌，(3) 子宫内膜癌与微生物失调。根据纳入和排除标准筛选文献，并采用叙事性综述评估量表对文献质量进行评价。 结果：肠道微生物组通过调节全身性炎症、免疫应答和雌激素代谢影响子宫内膜癌的发展，这些均是子宫内膜癌发生的关键因素。微生物失调是指微生物组成失衡，可导致慢性炎症和激素水平紊乱，从而促进子宫内膜癌的发生。同样，子宫内膜微生物组虽研究相对有限，但已证实可通过局部免疫调节和有害代谢产物生成等机制参与子宫内膜癌的发病过程。益生菌、益生元、粪菌移植以及基于微生物组的个体化疗法可作为子宫内膜癌管理的临床干预手段。本综述强调需进一步研究探索肠道-子宫内膜轴及其在创新治疗方法中的潜力。深入理解这些复杂的相互作用将成为预防和治疗子宫内膜癌的新策略，最终改善患者预后。
肿瘤(癌症)患者之家