文章：

Trends in Endometrial Cancer Incidence Among Premenopausal and Postmenopausal Women in the United States Between 2001 and 2021

原文发布日期：20 March 2025

DOI: 10.3390/cancers17061035

类型: Article

开放获取: 是

英文摘要：

Background: Endometrial cancer incidence has been rising in the United States. We assessed trends in endometrial cancer incidence among both premenopausal and postmenopausal women in the US from 2001 to 2021. We also compared the incidence during 2019–2021 to assess the impact of the COVID-19 pandemic. Methods: We used data from the United States Cancer Statistics 2001–2021 database to assess the incidence trends among adult females. Endometrial cancer incidence was corrected for hysterectomy prevalence and age, adjusted to the 2000 US standard population. Results: From 2001 to 2021, the incidence of endometrial cancer rose from 86.8 cases to 113.8 cases per 1,000,000 persons among women aged 20–49 years (APC 1.5, 95% CI 1.2–1.8), while in women 70 and older, it increased from 1326.4 cases to 1339.4 cases per 1,000,000 persons (APC 0.3, 95% CI 0.1–0.6). The incidence has recently decreased among women aged 50–69 years (APC from 2001 to 2016 0.3, 95% CI 0.1–0.9; APC from 2016 to 2021 −1.3, 95% CI −2.2–−0.3). Endometrial cancer incidence sharply increased from 2001 to 2021 among non-Hispanic Blacks, non-Hispanic Asians or Pacific Islanders, and women in the South. Endometrial cancer incidence sharply decreased from 2019 to 2020, and the proportion of metastatic cancer at diagnosis increased across all age groups. In 2021, the incidence returned to 2019 levels. Conclusions: Endometrial cancer incidence rates are rising, particularly among premenopausal women. During the beginning of the COVID-19 pandemic, the incidence rates decreased, but the proportion of metastatic cancer increased.

摘要翻译： 

背景：子宫内膜癌发病率在美国呈上升趋势。本研究评估了2001年至2021年美国绝经前与绝经后女性子宫内膜癌的发病趋势，并通过对比2019-2021年数据评估了COVID-19大流行的影响。方法：基于美国癌症统计2001-2021数据库，分析成年女性子宫内膜癌发病率变化趋势。数据经子宫切除术患病率校正及年龄标准化（参照2000年美国标准人口结构）。结果：2001年至2021年间，20-49岁女性子宫内膜癌发病率从每百万人86.8例上升至113.8例（年度变化百分比APC=1.5，95% CI 1.2-1.8）；70岁及以上女性从每百万人1326.4例增至1339.4例（APC=0.3，95% CI 0.1-0.6）。50-69岁女性发病率近期呈下降趋势（2001-2016年APC=0.3，95% CI 0.1-0.9；2016-2021年APC=-1.3，95% CI -2.2至-0.3）。非西班牙裔黑人、非西班牙裔亚洲或太平洋岛民及南部地区女性的发病率在2001-2021年间显著上升。2019至2020年子宫内膜癌发病率急剧下降，且所有年龄组确诊时转移性癌症比例均有所上升。至2021年，发病率已恢复至2019年水平。结论：子宫内膜癌发病率持续上升，尤其在绝经前女性群体中更为显著。COVID-19大流行初期发病率虽出现下降，但转移性癌症比例同步升高。

原文链接：

Trends in Endometrial Cancer Incidence Among Premenopausal and Postmenopausal Women in the United States Between 2001 and 2021