Background/Objectives: This study aims to evaluate the health-related quality of life (HRQoL) of children and adolescent cancer survivors in relation to previously published normative values for typically developing children and adolescents, as well as to analyze the differences in HRQoL based on their levels of physical activity and fitness.Methods: Cross-sectional study with 116 cancer survivors (12.1 ± 3.3 years, 57.8% boys) from two pediatric oncology units in Andalusia (Spain). HRQoL was assessed using PedsQL 4.0 Generic Core Scales. Physical activity was measured with accelerometers, and fitness was evaluated using self-reported and objective tests for muscular fitness. Independent samplest-tests to compare HRQoL between our sample and the normative values published for typically developing children and adolescents of the same age and analysis of covariance (ANCOVA) were conducted to assess differences in HRQoL according to physical activity and fitness categories in our sample.Results: Children and adolescent cancer survivors had lower HRQoL scores compared to typically developing children’s and adolescents’ normative values, except for social functioning. Higher levels of moderate-to-vigorous physical activity were associated with better total, physical, and psychosocial HRQoL scores. Children and adolescent cancer survivors with better levels of cardiorespiratory fitness, motor fitness, and flexibility reported better HRQoL scores in total and psychosocial domains. However, muscular fitness (self-reported and objectively measured) did not show a significant difference in HRQoL.Conclusions: Children and adolescent cancer survivors experience lower HRQoL than their typically developing counterparts. Engaging in at least 30 min of moderate-to-vigorous physical activity per day is associated with fewer HRQoL impairments. Improved fitness, particularly cardiorespiratory fitness, motor fitness, and flexibility, are associated with better HRQoL outcomes. These findings highlight the association between physical activity, fitness levels, and HRQoL in children and adolescent cancer survivors, suggesting the potential benefits of promoting physical activity and enhancing fitness levels.
背景/目的：本研究旨在评估儿童及青少年癌症幸存者的健康相关生活质量，并与已发表的正常发育儿童青少年常模数据进行比较，同时分析其HRQoL与体力活动水平及体能状况的关联性。 方法：采用横断面研究设计，纳入西班牙安达卢西亚地区两个儿科肿瘤中心的116名癌症幸存者（年龄12.1±3.3岁，男性占57.8%）。使用PedsQL 4.0通用核心量表评估HRQoL，通过加速度计测量体力活动水平，采用主客观结合方式评估肌肉适能。通过独立样本t检验比较本样本与同龄正常发育儿童青少年常模数据的HRQoL差异，并运用协方差分析评估本样本中不同体力活动与体能水平对HRQoL的影响。 结果：除社会功能维度外，儿童青少年癌症幸存者的HRQoL各维度得分均低于正常发育同龄人群常模。中高强度体力活动水平越高，其总体、生理及心理社会HRQoL得分越优。心肺适能、运动适能和柔韧性较好的幸存者在总体及心理社会HRQoL领域表现更佳，但肌肉适能（主客观测量）与HRQoL未呈现显著相关性。 结论：儿童青少年癌症幸存者的HRQoL普遍低于正常发育同龄人。每日保持至少30分钟中高强度体力活动与HRQoL损伤减轻相关。提升体能水平，特别是心肺适能、运动适能和柔韧性，有助于改善HRQoL。本研究揭示了体力活动、体能状况与儿童青少年癌症幸存者HRQoL的关联性，为通过促进体力活动和提升体能水平改善该群体生活质量提供了实证依据。
肿瘤(癌症)患者之家