Introduction: Vulvar cancer affects approximately 47,000 women annually worldwide. With most studies focusing on oncological outcomes, quality of life is often overlooked. There is a lack of knowledge on the influence of modifiable factors such as lifestyle on the quality of life of vulvar cancer survivors. This study evaluated the association between lifestyle factors and the quality of life of vulvar cancer survivors.Methods: This was a cross-sectional survey study of women who received surgical treatment for vulvar cancer ≥FIGO stage 1B at the Northern Gynecological Oncology Centre, UK, between 2013 and 2022. Baseline and clinical characteristics were collected from patient records. Godin Leisure-Time Exercise questionnaires were used to assess physical activity. BMI was assessed using self-reported height and weight. Quality of life was measured using the validated European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) and the vulvar cancer-specific module (VU-34). An analysis was performed using Mann–Whitney-U and Kruskal–Wallis tests.Results: Of the 299 women, 139 were eligible for participation, of whom 58 participated (41.7%). Twenty participants had a sedentary (40.8%), eight a moderately active (16.3%), and seventeen an active (34.7%) lifestyle. Active participants reported higher overall quality of life and higher functioning in all domains but not for vulvar-related symptoms or sexual functioning. Forty-nine participants disclosed their BMI, which was not associated with quality of life outcomes.Conclusions: A higher level of physical activity was associated with higher quality of life. No association was found between BMI and quality of life.
引言：全球每年约有47,000名女性罹患外阴癌。现有研究多聚焦于肿瘤学结局，患者生活质量常被忽视。关于生活方式等可调控因素对外阴癌幸存者生活质量的影响，目前尚缺乏深入研究。本研究旨在评估生活方式因素与外阴癌幸存者生活质量之间的关联。 方法：本研究采用横断面调查方法，纳入2013年至2022年间在英国北部妇科肿瘤中心接受手术治疗且分期≥FIGO 1B期外阴癌的女性患者。通过病历记录收集基线及临床特征，采用Godin休闲时间运动问卷评估体力活动水平，通过自报身高体重计算体重指数（BMI）。使用经验证的欧洲癌症研究与治疗组织生命质量核心量表（EORTC QLQ-C30）及外阴癌特异性模块（VU-34）评估生活质量。数据分析采用Mann-Whitney U检验和Kruskal-Wallis检验。 结果：在299例患者中，139例符合纳入标准，最终58例参与研究（参与率41.7%）。其中20例（40.8%）为久坐型生活方式，8例（16.3%）为中度活动型，17例（34.7%）为积极活动型。积极活动型参与者报告了更高的整体生活质量及所有功能领域评分，但外阴相关症状和性功能评分未见显著差异。49例参与者提供了BMI数据，分析显示BMI与生活质量结局无显著关联。 结论：较高水平的体力活动与更好的生活质量相关，而BMI与生活质量未发现显著关联。
The Effect of Lifestyle on the Quality of Life of Vulvar Cancer Survivors
肿瘤(癌症)患者之家