Background/Objectives: Comprehensive cancer centers (CCCs) remain at the forefront of cancer control efforts. Limited clarity and variation exist around the models, scope, characteristics, and impacts of CCCs around the globe. This scoping review systematically searched and synthesized the international literature, describing core attributes and anticipated and realized impacts of CCCs, detailing changes over time.Methods: Searches for English language sources were conducted across PubMed, Cochrane CENTRAL, Epistemonikos, and the gray literature from January 2002 to April 2024. Data were extracted and appraised by two authors. Results were narratively synthesized.Results: Of 3895 database records and 843 gray literature sources screened, 81 sources were included. Papers were predominantly opinion-based, from the USA and Europe, and published between 2011 and 2020. Internationally, the interconnected attributes of CCCs included (1) clinical service provision; (2) research, data, and innovation; (3) education and clinical support; (4) networks and leadership; (5) health equity and inclusiveness; and (6) accountability and governance. Largely anticipated impacts were synergistic and included delivery of optimal, person-centered, complex care; development of a highly qualified cancer workforce; greater research activity and funding; effective, strategic alliances; and reduction in cancer-related inequalities. Limited evidence was found demonstrating measurable broad outcomes of CCCs. The early literature highlighted the establishment, development, and accreditation of CCCs. The ongoing literature has reflected the evolution of cancer care, key areas for growth, and limitations of CCCs. Recently, the CCC literature has increased exponentially and focused on the need for CCCs to drive networks and leadership to address health equity and inclusiveness.Conclusions: Results suggest that CCCs are yet to reach their full potential, with future efforts ideally focusing on accountability, effective networking, and health equity at a local, national, and international level. CCCs must generate evidence of impact, and continue to evolve in line with contemporary healthcare, to fulfil their role in cancer control efforts.
背景/目的：综合性癌症中心（CCCs）始终处于癌症防治工作的前沿。目前全球范围内对CCCs的模式、范围、特征及影响尚缺乏明确共识且存在差异。本范围综述系统检索并整合了国际文献，描述了CCCs的核心属性、预期及实际影响，并详细阐述了其随时间推移的变化。 方法：在PubMed、Cochrane CENTRAL、Epistemonikos数据库及灰色文献中检索2002年1月至2024年4月发表的英文文献。由两位研究者独立完成数据提取与评估，并对结果进行叙述性整合。 结果：经筛选的3895条数据库记录和843份灰色文献中，最终纳入81篇文献。这些文献主要基于观点论述，多来自美国和欧洲，发表于2011至2020年间。国际范围内，CCCs相互关联的核心属性包括：（1）临床服务提供；（2）研究、数据与创新；（3）教育与临床支持；（4）网络与领导力；（5）健康公平与包容性；（6）问责与治理。其预期影响主要体现为协同效应，包括：提供优质、以人为本的复杂诊疗服务；培养高素质癌症防治人才；提升科研活动水平与资金投入；建立有效的战略联盟；减少癌症相关不平等现象。目前证明CCCs可量化广泛影响的证据有限。早期文献侧重于CCCs的建立、发展与认证；后续文献反映了癌症诊疗的发展演变、CCCs的关键增长领域及局限性；近期文献数量呈指数增长，重点关注CCCs需通过推动网络建设与领导力发展以促进健康公平与包容性。 结论：结果表明CCCs尚未充分发挥其潜力，未来工作应聚焦于在地方、国家和国际层面强化问责机制、建设有效网络及促进健康公平。CCCs必须提供其影响力的实证依据，并顺应现代医疗发展趋势持续演进，以实现在癌症防治工作中的核心作用。
肿瘤(癌症)患者之家