Background/Objectives: Chronic inflammation has been implicated in cancer development, but the association between allergic rhinitis (AR) and head and neck cancer (HNC) remains unclear. This study aims to investigate this potential relationship using a population-based dataset.Methods: Utilizing the Taiwan Longitudinal Health Insurance Database 2010, we conducted a case-control study encompassing 14,913 HNC patients and 59,652 propensity-score matched controls. Multivariate logistic regression analyses were performed to quantitatively evaluate the association between HNC and prior AR, adjusting for demographic factors and medical comorbidities such as hyperlipidemia, diabetes, hypertension, tobacco use disorder, HPV infection, and alcohol-related disorders.Results: This study identified that 20.19% of the entire cohort had a prior diagnosis of AR, with a significantly higher prevalence in HNC patients relative to controls (26.2% vs. 18.70%). The adjusted odds ratio (OR) for previous AR in HNC patients was 1.559 (95% CI = 1.494–1.627). Furthermore, site-specific analysis revealed increased odds ratios for AR among patients with cancers of the larynx (OR = 1.537, 95% CI = 1.307–1.807), hypopharynx (OR = 1.220, 95% CI = 1.035–1.437), nasopharynx (OR = 2.933, 95% CI = 2.722–3.160), sinonasal (OR = 3.100, 95% CI = 2.424–3.964), salivary glands (OR = 1.470, 95% CI = 1.158–1.865), and thyroid (OR = 1.566, 95% CI = 1.447–1.693).Conclusions: The findings robustly support a significant link between AR and an elevated risk of developing HNC, notably affecting the nasopharynx, sinonasal cavities, larynx, salivary glands, and thyroid.
背景/目的：慢性炎症被认为与癌症发生相关，但变应性鼻炎与头颈部癌症之间的关联尚不明确。本研究旨在基于人群数据探究这一潜在关系。 方法：利用台湾2010年纵向健康保险数据库，我们开展了一项病例对照研究，纳入14,913名头颈癌患者及59,652名经倾向评分匹配的对照者。通过多变量逻辑回归分析，在调整人口学因素及高脂血症、糖尿病、高血压、烟草使用障碍、HPV感染和酒精相关疾病等共病后，定量评估头颈癌与既往变应性鼻炎病史的关联性。 结果：研究发现全队列中20.19%的个体有变应性鼻炎既往诊断史，其中头颈癌患者的变应性鼻炎患病率显著高于对照组（26.2% vs. 18.70%）。经校正后，头颈癌患者既往患变应性鼻炎的比值比为1.559（95% CI = 1.494–1.627）。进一步按部位分析显示，喉癌（OR = 1.537，95% CI = 1.307–1.807）、下咽癌（OR = 1.220，95% CI = 1.035–1.437）、鼻咽癌（OR = 2.933，95% CI = 2.722–3.160）、鼻窦癌（OR = 3.100，95% CI = 2.424–3.964）、唾液腺癌（OR = 1.470，95% CI = 1.158–1.865）及甲状腺癌（OR = 1.566，95% CI = 1.447–1.693）患者中变应性鼻炎的比值比均显著升高。 结论：本研究结果有力证实了变应性鼻炎与头颈部癌症风险升高存在显著关联，尤其对鼻咽、鼻窦、喉部、唾液腺及甲状腺部位的癌症影响更为明显。
Associations of Head and Neck Cancer with Prior Allergic Rhinitis
肿瘤(癌症)患者之家