Background: Gastrointestinal tract cancers represent a significant worldwide health concern, accounting for almost one-third of cancer-related deaths. The existing chemotherapy drugs used in gastrointestinal cancers are ineffective, so prognosis is poor, recurrence and metastasis rates are high, and survival time remains short, necessitating the development of novel antitumor drugs that exhibit low toxicity and less potential for the development of drug resistance. This challenge is considerable, but evidence from the past decades supports the medicinal properties and functionalities of bioactive compounds such as flavonoids and acid phenolics with anticancer activities. Our purpose was to find data on the relationship between gastrointestinal cancer and bioactive compounds fromPrunusspecies, focusing on their molecular mechanisms of action. Results: Studies highlight the potential of bioactive compounds fromPrunusspecies to modulate the cancer cell signaling pathways involved in gastrointestinal tumorigenesis. Conclusions: The studies reviewed suggest that polyphenols fromPrunusspecies exhibit promising gastrointestinal anticancer activities and could represent an adjunctive therapeutic strategy in cancer treatment. Further studies are necessary to validate these compounds’ therapeutic potential and their feasibility as cost-effective treatments for cancer.
背景：胃肠道癌症是全球范围内一个重大的健康问题，约占癌症相关死亡的三分之一。目前用于胃肠道癌症的化疗药物效果不佳，因此预后较差，复发和转移率高，生存时间仍然较短，迫切需要开发具有低毒性和较低耐药性潜力的新型抗肿瘤药物。这一挑战相当艰巨，但过去几十年的证据支持具有抗癌活性的生物活性化合物（如黄酮类化合物和酸性酚类化合物）的药用特性和功能。我们的目的是寻找关于胃肠道癌症与李属植物生物活性化合物之间关系的数据，重点关注其分子作用机制。结果：研究强调了李属植物生物活性化合物在调节参与胃肠道肿瘤发生的癌细胞信号通路方面的潜力。结论：综述的研究表明，李属植物中的多酚类化合物展现出有前景的胃肠道抗癌活性，可能成为癌症治疗中的辅助治疗策略。需要进一步的研究来验证这些化合物的治疗潜力及其作为成本效益高的癌症治疗方法的可行性。
Therapeutic Potential ofPrunusSpecies in Gastrointestinal Oncology
肿瘤(癌症)患者之家