Cancer-related cognitive decline refers to a deterioration in cognitive function affecting adults with cancer at any stage of their cancer journey. Older adults are at increased risk of cognitive decline. As the indications for immune checkpoint inhibitors expand in the treatment of cancer, understanding the potential complicating cognitive issues experienced by those receiving this therapy will be important. The aim of this scoping review is to identify the literature regarding immune checkpoint inhibitors and subjective/objective decline, to identify evidence in older adults, differences between older and younger adults, and outline areas for further research. Four large electronic databases were searched. Records were screened using standardised methodology. Ten studies were identified that met the inclusion criteria for review. Six studies objectively evaluated cognitive function in adults receiving ICI treatment; eight studies performed subjective cognitive assessments. There were differences identified in the cognitive assessment tools used and the methodology between studies. Few studies reported on age-dependent findings. The results of this scoping review highlight the need for further research in this area using standardised methodology and testing, with a particular focus on the cognitive outcomes of older adults who may be at increased risk of developing cognitive decline while on treatment.
癌症相关认知衰退指的是在癌症病程的任何阶段，影响成年癌症患者认知功能下降的现象。老年患者面临更高的认知衰退风险。随着免疫检查点抑制剂在癌症治疗中的适应症不断扩大，了解接受该疗法患者可能出现的认知并发症至关重要。本范围综述旨在梳理关于免疫检查点抑制剂与主客观认知衰退的文献，明确老年群体的相关证据、年龄差异特征，并指出未来研究方向。通过检索四大电子数据库，采用标准化方法筛选文献，最终纳入符合标准的10项研究。其中6项研究对接受免疫检查点抑制剂治疗的成人患者进行了客观认知功能评估，8项研究实施了主观认知评估。研究发现各研究在认知评估工具和方法学上存在差异，且针对年龄相关发现的研究较少。本综述结果强调，该领域需采用标准化方法开展进一步研究，特别应关注治疗期间认知衰退风险更高的老年患者的认知结局。
Immune Checkpoint Inhibitors and Cognition in Adults with Cancer: A Scoping Review
肿瘤(癌症)患者之家